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The gradual growth in sex difference throughout a person's life is a product of various hormones. Testosterone is the major active hormone in male development while estrogen is the dominant female hormone. These hormones are not, however, limited to each sex. Both males and females have both testosterone and estrogen. [107]
In women, low levels of estrogen may cause symptoms such as hot flashes, sleeping disturbances, decreased bone health, [3] and changes in the genitourinary system. Hypoestrogenism is most commonly found in women who are postmenopausal , have primary ovarian insufficiency (POI), or are presenting with amenorrhea (absence of menstrual periods ).
Estrogen is associated with edema, including facial and abdominal swelling. Melanin. Estrogen is known to cause darkening of skin, especially in the face and areolae. [38] Pale skinned women will develop browner and yellower skin during pregnancy, as a result of the increase of estrogen, known as the "mask of pregnancy". [39]
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The volumes of sexually dimorphic brain structures in transgender women were found to change and approximate typical female brain structures when exposed to estrogen concomitantly with androgen deprivation over a period of months, [31] suggesting that estrogen and/or androgens have a significant part to play in sex differentiation of the brain ...
Complete androgen insensitivity syndrome causes a genetic male to have a vagina (often incompletely developed, nearly always blind-ending), breasts, and a clitoris; people with this form are raised as females. [25] Aphallia – a rare condition where a XY male is born without a penis. As of 2017, only 100 cases have been reported in literature ...
Testosterone is the primary androgen — or male hormone — in your body. Low testosterone affects up to 39 percent of adult men in the US over the age of 45, and becomes increasingly prevalent ...
Estrogen insensitivity syndrome (EIS), or estrogen resistance, is a form of congenital estrogen deficiency or hypoestrogenism [2] which is caused by a defective estrogen receptor (ER) – specifically, the estrogen receptor alpha (ERα) – that results in an inability of estrogen to mediate its biological effects in the body. [3]