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Xerostomia is the subjective sensation of dry mouth, which is often (but not always) associated with hypofunction of the salivary glands. [3] The term is derived from the Greek words ξηρός (xeros) meaning "dry" and στόμα (stoma) meaning "mouth". [4] [5] A drug or substance that increases the rate of salivary flow is termed a sialogogue.
Pilocarpine stimulates the secretion of large amounts of saliva and sweat. [16] It is used to prevent or treat dry mouth, particularly in Sjögren syndrome, but also as a side effect of radiation therapy for head and neck cancer. [17] It may be used to help differentiate Adie syndrome from other causes of unequal pupil size. [18] [19]
The following are used in dentistry to treat xerostomia: [3] Parasympathomimetic drugs act on parasympathetic muscarinic receptors to induce an increased saliva flow. The M3 receptor has been identified as the principal target to increase salivary flow rates. [4] Pilocarpine is an example; the maximum dose of this drug is 30 mg/day ...
Xerostomia, or a decrease in saliva flow, can be a side effect of many drugs, which, in turn, can lead to the development of taste disturbances such as dysgeusia. [39] Patients can lessen the effects of xerostomia with breath mints, sugarless gum, or lozenges; or physicians can increase saliva flow with artificial saliva or oral pilocarpine. [39]
Dry mouth (xerostomia) is frequently caused by medication and to a lesser extent, by anxiety or Sjögren's syndrome. [6] It can be useful to have the extent of dryness recorded. That is, if a person has a complaint of a dry mouth, the clinician can apply the Challacombe scale to determine its severity and whether treatment is required.
Pilocarpine is a drug that acts as a muscarinic receptor agonist that is used to treat glaucoma Cevimeline (AF102B) (Evoxac®) is a muscarinic agonist that is a Food and Drug Administration (FDA)- approved drug and used for the management of dry mouth in Sjögren's syndrome
Pilocarpine — a similar parasympathomimetic medication for dry mouth Bethanechol — a similar muscarinic parasympathomimetic with longer-lasting effect References
OMD in adult and geriatric populations are due to various neurological impairments, oral hygiene, altered functioning of muscles due to aging, systemic diseases, etc. Tongue thrusting is a type of orofacial myofunctional disorder, which is defined as habitual resting or thrusting the tongue forward and/or sideways against or between the teeth ...
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