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Xerostomia is the subjective sensation of dry mouth, which is often (but not always) associated with hypofunction of the salivary glands. [3] The term is derived from the Greek words ξηρός (xeros) meaning "dry" and στόμα (stoma) meaning "mouth". [4] [5] A drug or substance that increases the rate of salivary flow is termed a sialogogue.
Pilocarpine stimulates the secretion of large amounts of saliva and sweat. [16] It is used to prevent or treat dry mouth, particularly in Sjögren syndrome, but also as a side effect of radiation therapy for head and neck cancer. [17] It may be used to help differentiate Adie syndrome from other causes of unequal pupil size. [18] [19]
The following are used in dentistry to treat xerostomia: [3] Parasympathomimetic drugs act on parasympathetic muscarinic receptors to induce an increased saliva flow. The M3 receptor has been identified as the principal target to increase salivary flow rates. [4] Pilocarpine is an example; the maximum dose of this drug is 30 mg/day ...
Xerostomia, or a decrease in saliva flow, can be a side effect of many drugs, which, in turn, can lead to the development of taste disturbances such as dysgeusia. [39] Patients can lessen the effects of xerostomia with breath mints, sugarless gum, or lozenges; or physicians can increase saliva flow with artificial saliva or oral pilocarpine. [39]
Chronic dry mouth is prevalent in a high proportion of the elderly population, affecting roughly one fifth of the group. [25] There has been a link between dry mouth and comorbid diseases including diabetes , Alzheimer's or Parkinson's disease [ 14 ] [ 16 ] Additionally, xerostomia can arise from general dehydration . [ 26 ]
Pilocarpine is a drug that acts as a muscarinic receptor agonist that is used to treat glaucoma Cevimeline (AF102B) (Evoxac®) is a muscarinic agonist that is a Food and Drug Administration (FDA)- approved drug and used for the management of dry mouth in Sjögren's syndrome
It is used in the treatment of dry mouth and Sjögren's syndrome. Medical uses ... Pilocarpine — a similar parasympathomimetic medication for dry mouth ...
People with BMS are more likely to be middle aged or elderly, and females are three to seven times more likely to have BMS than males. [1] [29] Some report a female to male ratio of as much as 33 to 1. [6] BMS is reported in about 10–40% of women seeking medical treatment for menopausal symptoms, and BMS occurs in about 14% of postmenopausal ...
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