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  2. Activator (genetics) - Wikipedia

    en.wikipedia.org/wiki/Activator_(genetics)

    A transcriptional activator is a protein (transcription factor) that increases transcription of a gene or set of genes. [1] Activators are considered to have positive control over gene expression, as they function to promote gene transcription and, in some cases, are required for the transcription of genes to occur.

  3. Regulation of transcription in cancer - Wikipedia

    en.wikipedia.org/wiki/Regulation_of...

    In humans, about 70% of promoters located near the transcription start site of a gene (proximal promoters) contain a CpG island. [1] [2] CpG islands are generally 200 to 2000 base pairs long, have a C:G base pair content >50%, and have regions of DNA where a cytosine nucleotide is followed by a guanine nucleotide and this occurs frequently in the linear sequence of bases along its 5′ → 3 ...

  4. JAK-STAT signaling pathway - Wikipedia

    en.wikipedia.org/wiki/JAK-STAT_signaling_pathway

    Like many other transcription factors, STATs are capable of recruiting co-activators such as CBP and p300, and these co-activators increase the rate of transcription of target genes. [2] The coactivators are able to do this by making genes on DNA more accessible to STATs and by recruiting proteins needed for transcription of genes.

  5. p53 - Wikipedia

    en.wikipedia.org/wiki/P53

    Activation of p53 in response to stress signals initiates its transcriptional activity, leading to the activation of cellular protective pathways [25] p53 binds to the DNA in a tetrameric configuration and promotes the transcription of a wide array of genes. Pictured are key p53 pathways and transcriptional targets regulated by p53 with a ...

  6. STAT3 - Wikipedia

    en.wikipedia.org/wiki/STAT3

    STAT3 is a member of the STAT protein family. In response to cytokines and growth factors, STAT3 is phosphorylated by receptor-associated Janus kinases (JAK), forms homo- or heterodimers, and translocates to the cell nucleus where it acts as a transcription activator.

  7. TCF/LEF family - Wikipedia

    en.wikipedia.org/wiki/TCF/LEF_family

    The TCF/LEF family (T cell factor/lymphoid enhancer factor family) is a group of genes that encode transcription factors which bind to DNA through a SOX-like high mobility group domain. They are involved in the Wnt signaling pathway , particularly during embryonic [ 2 ] and stem-cell development, [ 3 ] but also had been found to play a role in ...

  8. Artificial transcription factor - Wikipedia

    en.wikipedia.org/wiki/Artificial_transcription...

    3. After the activating protein complex binds to the promoter, RNA polymerase easily binds and starts transcribing the target gene. 4. and 5. are additional scenarios where in 4. an insulator/inhibitor can bind to the DNA preventing activation for transcription and in 5. methylation can prevent the insulator from binding.

  9. Mediator (coactivator) - Wikipedia

    en.wikipedia.org/wiki/Mediator_(coactivator)

    This appears to be accomplished by phosphorylation of part of the polymerase by a kinase. Importantly, mediator and transcription factors do not dissociate from the DNA at the time polymerase begins transcription. Rather, the complex remains at the promoter to recruit another RNA polymerase to begin another round of transcription. [3] [h]

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