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Cevimeline (trade name Evoxac) is a synthetic analog of the natural alkaloid muscarine with a particular agonistic effect on M 1 and M 3 receptors. It is used in the treatment of dry mouth and Sjögren's syndrome .
Pilocarpine is a drug that acts as a muscarinic receptor agonist that is used to treat glaucoma Cevimeline (AF102B) (Evoxac®) is a muscarinic agonist that is a Food and Drug Administration (FDA)- approved drug and used for the management of dry mouth in Sjögren's syndrome
Pilocarpine, sold under the brand name Pilopine HS among others, is a lactone alkaloid originally extracted from plants of the Pilocarpus genus. [4] It is used as a medication to reduce pressure inside the eye and treat dry mouth .
CHRM1 Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5CXV Identifiers Aliases CHRM1, HM1, M1, M1R, cholinergic receptor muscarinic 1 External IDs OMIM: 118510 ; MGI: 88396 ; HomoloGene: 20189 ; GeneCards: CHRM1 ; OMA: CHRM1 - orthologs Gene location (Human) Chr. Chromosome 11 (human) Band 11q12.3 Start 62,908,679 bp End 62,921,807 bp Gene location (Mouse) Chr ...
A parasympathomimetic drug, sometimes called a cholinomimetic drug [1] or cholinergic receptor stimulating agent, [2] is a substance that stimulates the parasympathetic nervous system (PSNS).
Apraclonidine has been compared with other treatments such as brimonidine and pilocarpine in preventing IOP spikes after laser trabeculoplasty. [2] The results did not show significant differences in the reduction of IOP for apraclonidine, when compared to brimonidine or pilocarpine. [2]
A motivation-enhancing drug, [2] [3] also known as a pro-motivational drug, [1] is a drug which increases motivation. [4] [1] Drugs enhancing motivation can be used in the treatment of motivational deficits, for instance in depression, schizophrenia, and attention deficit hyperactivity disorder (ADHD).
Paraoxon and rivastigmine are both acetylcholinesterase inhibitors and butyrylcholinesterase inhibitors. [14] [11] [7]In 2015, the United States Food and Drug Administration's Adverse Event Reporting System database compared rivastigmine to the other ChEI drugs donepezil and galantamine found that rivastigmine was associated with a higher frequency of reports of death as an adverse event.
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