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Testosterone cypionate is a testosterone ester and a long-lasting prodrug of testosterone in the body. [7] [2] [3] Because of this, it is considered to be a natural and bioidentical form of testosterone. [14] Testosterone cypionate was introduced for medical use in 1951.
Levels of testosterone with intramuscular injections of testosterone cypionate were about 700 ng/dL for 100 mg/week, 1100 ng/dL for 250 mg/week, and 2000 ng/dL for 500 mg/week. [75] [76] In another study, testosterone levels with 600 mg/week testosterone enanthate by intramuscular injection were 2,800–3,200 ng/dL. [75] [77]
Testosterone cypionate and testosterone enanthate were formerly available in combination with estradiol cypionate and estradiol valerate, respectively, under the brand names Depo-Testadiol and Ditate-DS, respectively, as oil solutions for intramuscular injection, but these formulations have been discontinued.
Intramuscular injection: 13.0 days: 20.9 days: 34.9 days Testosterone undecanoate: Castor oil solution: Intramuscular injection: 11.4 days: 33.9 days: 36.0 days Testosterone buciclate a: Aqueous suspension: Intramuscular injection: 25.8 days: 29.5 days: 60.0 days Notes: Testosterone cypionate has similar pharmacokinetics to Testosterone ...
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The lipophilicity of the cypionate group allows the prodrug to be sequestered in fat depots after intramuscular injection. [2] The ester group is slowly hydrolyzed by metabolic enzymes, releasing steady doses of the active ingredient.
Testosterone propionate (Testosterone Propionate (generic)), testosterone cypionate/estradiol cypionate (brand name Depo-Testadiol), testosterone enanthate/estradiol valerate (brand name Ditate-DS) as oil solutions for intramuscular injection were previously available but were discontinued.
Injection (IM Tooltip intramuscular injection or SC Tooltip subcutaneous injection) Testosterone propionate: Oil solution: 50–100 mg 3x/week Testosterone enanthate: Oil solution: 200–400 mg 1x/2–4 weeks Testosterone cypionate: Oil solution: 200–400 mg 1x/2–4 weeks Mixed testosterone esters: Oil solution: 250 mg 1x/week Methandriol ...
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