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CD25 consists of three domains: extracellular (N-terminus), transmembrane (alpha-helix) and cytoplasmic (C-terminus). However, while extracellular part is able to function as a binding site for interleukin-2 , short cytoplasmic domain lacks an ability to induce intracellular signalling and therefore needs to oligomerise with other IL-2 receptor ...
IL-2 binds to the IL-2 receptor, which has three forms, generated by different combinations of three different proteins, often referred to as "chains": α (alpha) (also called IL-2Rα, CD25, or Tac antigen), β (beta) (also called IL-2Rβ, or CD122), and γ (gamma) (also called IL-2Rγ, γ c, common gamma chain, or CD132); these subunits are also parts of receptors for other cytokines.
CD25 deficiency or interleukin 2 receptor alpha deficiency is an immunodeficiency disorder associated with mutations in the interleukin 2 receptor alpha (CD25) (IL2RA) gene. The mutations cause expression of a defective α chain or complete absence thereof, an essential part of high-affinity interleukin-2 (IL-2) receptors.
Mature CD25+Foxp3+ Tregs can be also divided into two different subsets based on the expression level of CD25, GITR, and PD-1. Tregs expressing low amounts of CD25, GITR and PD-1 limit the development of colitis by promoting the conversion of conventional CD4 + T cells into pTreg. Tregs highly expressing CD25, GITR and PD-1 are more self ...
16183 Ensembl ENSG00000109471 ENSMUSG00000027720 UniProt P60568 P04351 RefSeq (mRNA) NM_000586 NM_008366 RefSeq (protein) NP_000577 NP_032392 Location (UCSC) Chr 4: 122.45 – 122.46 Mb Chr 3: 37.17 – 37.18 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Interleukin-2 (IL-2) is an interleukin, which is a type of cytokine signaling molecule forming part of the immune system. It is a ...
The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2.The low affinity form is a monomer of the alpha subunit (also called CD25) and is not involved in signal transduction.
In turn, this results in the T cell acquiring an activated phenotype seen by the up-regulation of surface markers CD25 +, CD44 +, CD62L low, CD69 + and may further differentiate into a memory T cell. Having adequate numbers of naive T cells is essential for the immune system to continuously respond to unfamiliar pathogens.
In humans, ILC2s express CRTH2, KLRG1, SST2, CD161, and CD25. [3] In mice, ILC2s express CD44, but not CD161. [3] ILC2s require IL-7 for their development, activating the fundamental transcription factors RORα and GATA3. GATA3 is also required for maintenance of ILC2 function, with GATA3 deprivation inhibiting the development and function of ...