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The highest surface expression of this protein is on regulatory T cells (Tregs), where CD25 is expressed constitutively, especially on a subset classified as naturally occurring Tregs. It can also be found on activated B cells , NK (natural killer) cells , thymocytes , and some myeloid lineage cells (e.g. macrophages , dendritic cells ).
IL-2 binds to the IL-2 receptor, which has three forms, generated by different combinations of three different proteins, often referred to as "chains": α (alpha) (also called IL-2Rα, CD25, or Tac antigen), β (beta) (also called IL-2Rβ, or CD122), and γ (gamma) (also called IL-2Rγ, γ c, common gamma chain, or CD132); these subunits are also parts of receptors for other cytokines.
CD25 deficiency or interleukin 2 receptor alpha deficiency is an immunodeficiency disorder associated with mutations in the interleukin 2 receptor alpha (CD25) (IL2RA) gene. The mutations cause expression of a defective α chain or complete absence thereof, an essential part of high-affinity interleukin-2 (IL-2) receptors.
As defined by CD4 and CD25 expression, regulatory T cells comprise about 5–10% of the mature CD4 + T cell subpopulation in mice and humans, while about 1–2% of T reg can be measured in whole blood. The additional measurement of cellular expression of FOXP3 protein allowed a more specific analysis of T reg cells (CD4 + CD25 + FOXP3 + cells).
Luteolin helped to decrease the transcript expression levels of an aging marker while increasing the “transcript expression level of endothelin-1.” The authors noted that this may indicate ...
16183 Ensembl ENSG00000109471 ENSMUSG00000027720 UniProt P60568 P04351 RefSeq (mRNA) NM_000586 NM_008366 RefSeq (protein) NP_000577 NP_032392 Location (UCSC) Chr 4: 122.45 – 122.46 Mb Chr 3: 37.17 – 37.18 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Interleukin-2 (IL-2) is an interleukin, which is a type of cytokine signaling molecule forming part of the immune system. It is a ...
The snow from this year’s Sundance Film Festival has mostly melted off of Hollywood’s Dior boots, and as the Utah event draws to a close the time has come to crown a new class of indie ...
The expression "From the River to the Sea" is a hotly disputed phrase in Israel, often taken as a call for Israel's destruction and a denial of its right to exist, although many Palestinians ...