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Sertraline, sold under the brand name Zoloft among others, is an antidepressant medication of the selective serotonin reuptake inhibitor (SSRI) class [10] used to treat major depressive disorder, generalized anxiety disorder, social anxiety disorder, obsessive–compulsive disorder (OCD), panic disorder, and premenstrual dysphoric disorder. [11]
Paroxetine was the first drug to be approved for social anxiety disorder and it is considered effective for this disorder; sertraline and fluvoxamine were later approved for it as well. Escitalopram and citalopram are used off-label with acceptable efficacy, while fluoxetine is not considered to be effective for this disorder. [ 22 ]
Based on this percentage, free concentrations of sertraline would be 2.49 ng/mL (8.13 nM) at the very most, which is only about one-third of the K i value that Tatsumi et al. found with sertraline at the DAT. [8] A very high dosage of sertraline of 400 mg/day has been found to produce peak plasma concentrations of about 250 ng/mL (816 nM). [16]
Adjusting your dosage of Zoloft. Zoloft is prescribed at several dosages, from 25mg to 200mg per day. Some side effects, including intimate effects, may be more common when Zoloft is used at a ...
Emma Bray, 25, took her own life 17 days after her sertraline dosage had been increased, with Laura Johnson, an assistant coroner for east London, stating in a PFD report: “Risks associated with ...
Serotonin. A serotonin reuptake inhibitor (SRI) is a type of drug which acts as a reuptake inhibitor of the neurotransmitter serotonin (5-hydroxytryptamine, or 5-HT) by blocking the action of the serotonin transporter (SERT).
Zoloft – an antidepressant of the SSRI class; Zonegran (zonisamide) – an anticonvulsant used to treat other seizures; Zulresso (brexanolone) – a GABA modulator antidepressant; Zyban (bupropion) – same active ingredient as Wellbutrin, but marketed as a smoking cessation aid
In tablet form, it’s available in three different strengths: 5mg, 10mg and 20mg tablets. For depression, escitalopram is normally prescribed at a dosage of 10mg to 20mg, taken one time per day.