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2. Metformin - Wikipedia

   en.wikipedia.org/wiki/Metformin

   Metformin inhibits cyclic AMP production, blocking the action of glucagon, and thereby reducing fasting glucose levels. [117] Metformin also induces a profound shift in the faecal microbial community profile in diabetic mice, and this may contribute to its mode of action possibly through an effect on glucagon-like peptide-1 secretion. [108]

3. Is There a Best Time to Take Metformin? - AOL

   www.aol.com/best-time-metformin-165700094.html

   People with type 2 diabetes take metformin to help control high blood sugar levels. Diabetes can cause many health issues, including sexual health challenges like erectile dysfunction (ED).

4. Peak-to-trough ratio - Wikipedia

   en.wikipedia.org/wiki/Peak-to-trough_ratio

   Peak-to-trough ratio in pharmacokinetics is the ratio of peak (C max) and trough (C min) levels of a drug over its dosing interval (τ) at steady state.. Peak-to-trough ratio (PTR), also known as peak-to-trough variation or peak-to-trough fluctuation, is a parameter in pharmacokinetics which is defined as the ratio of C max (peak) concentration and C min (trough) concentration over a dosing ...

5. Biological half-life - Wikipedia

   en.wikipedia.org/wiki/Biological_half-life

   Caesium in the body has a biological half-life of about one to four months. Mercury (as methylmercury) in the body has a half-life of about 65 days. Lead in the blood has a half life of 28–36 days. [29] [30] Lead in bone has a biological half-life of about ten years. Cadmium in bone has a biological half-life of about 30 years.

6. How Long Will It Take to Lose Weight on Metformin?

   www.aol.com/long-does-metformin-weight-loss...

   Among the 199 participants, 154 took a daily dose of up to 2,500mg of metformin for six months — the average metformin dose was 2,230mg daily. The remaining 45 participants weren’t treated ...

7. Cmax (pharmacology) - Wikipedia

   en.wikipedia.org/wiki/Cmax_(pharmacology)

   C max is the maximum (or peak) serum concentration that a drug achieves in a specified compartment or test area of the body after the drug has been administered and before the administration of a second dose. [1] It is a standard measurement in pharmacokinetics.

8. Scientists Explain What It Means If We’ve Reached Peak Human ...

   www.aol.com/lifestyle/scientists-explain-means...

   New research suggests that we may have reached peak human life span. Experts explain the findings and how to boost longevity.

9. Pharmacokinetics - Wikipedia

   en.wikipedia.org/wiki/Pharmacokinetics

   Population pharmacokinetics seeks to identify the measurable pathophysiologic factors and explain sources of variability that cause changes in the dose-concentration relationship and the extent of these changes so that, if such changes are associated with clinically relevant and significant shifts in exposures that impact the therapeutic index ...