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Androgen receptor antagonistic potency of spironolactone, cyproterone acetate, and flutamide in castrated male rats treated with exogenous testosterone (as measured by inhibition of androgen-dependent ventral prostate weight). [27] Spironolactone is an antagonist of the AR, the biological target of androgens like testosterone and DHT.
Flibanserin [1] and Bremelanotide [3] were developed for raising sexual desire in women, whereas similar conditions in men are treated using medications for sexual dysfunction. [4] On the other hand, down-regulation on libido comes in two approaches: a direct or an indirect mechanism.
Spironolactone can cause breast pain and breast enlargement in women. [ 128 ] [ 129 ] This is "probably because of estrogenic effects on target tissue." [ 111 ] At low doses, breast tenderness has been reported in only 5% of women, but at high doses, it has been reported in up to 40% of women.
Over on the male side, Dr. Primack says that obesity is often the cause of male breast growth. “Male breast growth is often caused by an imbalance of estrogen levels.
Many drugs can cause loss of libido as a side effect. [12] Since a partial cause of the refractory period is the inhibition of dopamine by an orgasm-induced secretion of prolactin, [13] such potent dopamine receptor agonists as cabergoline may help achieve multiple orgasms as well as the retention of sexual arousal for longer periods of time. [13]
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As with men, various medical problems, psychiatric problems (such as mood disorders), or increased amounts of prolactin can cause HSDD. Other hormones are believed to be involved as well. [citation needed] Additionally, factors such as relationship problems or stress are believed to be possible causes of reduced sexual desire in women ...
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