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Sealedenvelope.com is British collaboration that provides support services for clinical trials. They provide services such as randomization , allocation concealment , code-break services , and case report management through a web-based design.
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In a randomized experiment, allocation concealment hides the sorting of trial participants into treatment groups so that this knowledge cannot be exploited. Adequate allocation concealment serves to prevent study participants from influencing treatment allocations for subjects.
A code-break procedure is a set of rules which determine when planned unblinding should occur in a blinded experiment.FDA guidelines recommend that sponsors of blinded trials include a code-break procedure in their standard operating procedure.
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