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Ancient DNA (aDNA) is DNA isolated from ancient sources (typically specimens, ... The bone that is most often used for DNA extraction is the petrous ear bone, ...
To avoid contamination it is necessary to take many precautions such as separate ventilation systems and workspaces for ancient DNA extraction work. [22] The best samples to use are fresh fossils as uncareful washing can lead to mold growth. [20] DNA coming from fossils also occasionally contains a compound that inhibits DNA replication. [23]
Paleogenomics is a field of science based on the reconstruction and analysis of genomic information in extinct species.Improved methods for the extraction of ancient DNA (aDNA) from museum artifacts, ice cores, archeological or paleontological sites, and next-generation sequencing technologies have spurred this field.
DNA recovered from the bones of ancient Europeans is shedding light on the genetic origins of the debilitating disease multiple sclerosis. Gene that protected humans 5,000 years ago may be linked ...
Ancient DNA recovered from Pompeii shows that people found holding one another beneath the volcanic ash weren’t related in the ways we think. DNA analysis upends long-held assumptions about ...
Ancient DNA extracted from skeletons in burial sites across England shows evidence of mass migration from Europe and movement of people from as far as West Africa, challenging perceptions that ...
The femur was found to contain both mtDNA and nuclear DNA. Improvements in DNA extraction and library preparation techniques allowed for mtDNA to be successfully isolated and sequenced, however the nuclear DNA was found to be too degraded in the observed specimen, and was also contaminated with DNA from an ancient cave bear (Ursus deningeri ...
Pathogen DNA detection in ancient remains can be achieved with laboratory or computational methods. In both cases, the procedure starts with the extraction of DNA from ancient specimens. The laboratory methods are based on the construction of NGS libraries and the subsequent capture-based screening.