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Arteriosclerosis obliterans is an occlusive arterial disease most prominently affecting the abdominal aorta and the small- and medium-sized arteries of the lower extremities, which may lead to absent dorsalis pedis, posterior tibial, and/or popliteal artery pulses. [1]: 842
The prognosis for patients with peripheral vascular disease due to atherosclerosis is poor; patients with intermittent claudication due to atherosclerosis are at increased risk of death from cardiovascular disease (e.g. heart attack), because the same disease that affects the legs is often present in the arteries of the heart. [8]
Arteriosclerosis, literally meaning "hardening of the arteries", is an umbrella term for a vascular disorder characterized by abnormal thickening, hardening, and loss of elasticity [3] of the walls of arteries; [4] this process gradually restricts the blood flow to one's organs and tissues and can lead to severe health risks brought on by atherosclerosis, which is a specific form of ...
This leads to an occlusion of the artery and thus ischemia. Unlike embolic causes of limb ischemia, thrombosis is progressive and develops over time. In hypercoagulable states, thrombosis can occur in areas without atherosclerosis, and usually presents in patients with malignancy, increased tendency for blood to clot, or low blood flow. [15]
Atherosclerosis [a] is a pattern of the disease arteriosclerosis, [8] characterized by development of abnormalities called lesions in walls of arteries. This is a chronic inflammatory disease involving many different cell types and driven by elevated levels of cholesterol in the blood. [ 9 ]
451.1 Of deep vessels of lower extremities. 451.11 Deep vein thrombosis, femoral; 451.19 Deep vein thrombosis, other leg veins; 451.8 Of other sites 451.82 Phlebitis, superficial veins, upper extrem. 451.9 Thrombophlebitis, unspec. 452 Portal vein thrombosis; 453 Other venous embolism and thrombosis. 453.4 Deep vein thrombosis, unspec.
Smokers have up to a 10-fold increase in the risk of PAD in a dose-response relationship. [35] Exposure to second-hand smoke has also been shown to promote changes in the lining of blood vessels (endothelium), which can lead to atherosclerosis. Smokers are 2–3 times more likely to have lower extremity PAD than coronary artery disease. [39]
Atherosclerosis in the aorta and other large blood vessels is a common risk factor, [2] both for thromboembolism and cholesterol embolism. The legs and feet are major impact sites for these types. [2] Thus, risk factors for atherosclerosis are risk factors for arterial embolisation as well: advanced age [1] cigarette smoking [1] [2]
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