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The observation of high rates of autoimmune disorders in families with a history of Sjögren's syndrome is linked with a genetic predisposition to the syndrome. [34] Studies on the polymorphisms of human leukocyte antigen (HLA)-DR and HLA-DQ gene regions in Sjögren's patients show differential susceptibility to the syndrome as the result of ...
[1]: 485 [2]: 564 [3] It can be identified by a triad of medical disorders. The first is ichthyosis, which is a buildup of skin to form a scale-like covering that causes dry skin and other problems. The second identifier is paraplegia which is characterized by leg spasms.
Some women with autoimmune diseases may have problems getting pregnant. This can happen for many reasons such as medication types or even disease types. [59] Tests can tell if fertility problems are caused by an autoimmune disease or an unrelated reason. Fertility treatments are able to help some women with autoimmune disease become pregnant. [2]
A class of diseases, some of which may be autoimmune. Erythroblastosis fetalis: Mother's immune system attacks fetus. An immune system disorder but not autoimmune. Fibrodysplasia ossificans progressiva: Possibly an immune system disorder but not autoimmune. Gastrointestinal pemphigoid: No consistent evidence of association with autoimmunity.
The estimated community prevalence, which takes into account the observation that many people have more than one autoimmune disease, was 4.5% overall, with 2.7% for males and 6.4% for females. [74] A 2024 estimate was that 1 in 15 people in the U.S. had at least one autoimmune disease. [76]
The presentation of the disease varies considerably from one patient to another. [8] Generally, the symptoms include nonspecific symptoms common to connective tissue diseases such as fatigue – this is common in autoimmune diseases, and is the patient's primary concern [9] malaise; fever [10] These can be the initial presentation for some ...
Gen Z women were nearly three times more likely than Gen Z men to identify as LGBTQ. Bisexuals made up the highest percentage of LGBTQ respondents, at 57.3% — or 4.4% of all adults surveyed.
Marinesco–Sjögren-like syndrome is a very rare genetic disorder which is characterized by symptoms similar to those shown by people with Marinesco–Sjögren syndrome, the symptoms (of this variant of MSS) being infantile hypotonia, ataxia, cataracts, intellectual disabilities, cerebellar atrophy, myopathic alterations, vascular degeneration ...