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18205 Ensembl ENSG00000185652 ENSMUSG00000049107 UniProt P20783 P20181 RefSeq (mRNA) NM_001102654 NM_002527 NM_001164034 NM_001164035 NM_008742 RefSeq (protein) NP_001096124 NP_002518 NP_001157506 NP_001157507 NP_032768 Location (UCSC) Chr 12: 5.43 – 5.52 Mb Chr 6: 126.08 – 126.14 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Neurotrophin-3 is a protein that in humans is ...
Tropomyosin receptor kinase C (TrkC), [5] also known as NT-3 growth factor receptor, neurotrophic tyrosine kinase receptor type 3, or TrkC tyrosine kinase is a protein that in humans is encoded by the NTRK3 gene. [6] TrkC is the high affinity catalytic receptor for the neurotrophin NT-3 (neurotrophin-3).
The p75 neurotrophin receptor (p75NTR) was first identified in 1973 as the low-affinity nerve growth factor receptor (LNGFR) [5] [6] before discovery that p75NTR bound other neurotrophins equally well as nerve growth factor. [7] [8] p75NTR is a neurotrophic factor receptor.
Whereas neurotrophic factors within the neurotrophin family commonly have a protein tyrosine kinase receptor (Trk), Neurotrophin-3 (NT-3) has the unique receptor, TrkC. [8] In fact, the discovery of the different receptors helped differentiate scientists' understanding and classification of NT-3. [ 13 ]
Tropomyosin receptor kinase B is the high affinity catalytic receptor for several "neurotrophins", which are small protein growth factors that induce the survival and differentiation of distinct cell populations. The neurotrophins that activate TrkB are: BDNF (Brain Derived Neurotrophic Factor), neurotrophin-4 (NT-4), and neurotrophin-3 (NT-3).
Anti-NMDA receptor encephalitis is a type of brain inflammation caused by antibodies. [4] Early symptoms may include fever, headache, and feeling tired. [1] [2] This is then typically followed by psychosis which presents with false beliefs (delusions) and seeing or hearing things that others do not see or hear (hallucinations). [1]
The common ligands of trk receptors are neurotrophins, a family of growth factors critical to the functioning of the nervous system. [3] The binding of these molecules is highly specific. Each type of neurotrophin has different binding affinity toward its corresponding Trk receptor. The activation of Trk receptors by neurotrophin binding may ...
The Kasukawa criteria require a minimum of one of the common symptoms, a positive anti-RNP antibody, as well as one or more symptoms of the mixed symptoms in at least two of the three disease categories to qualify for a diagnosis of MCTD. [69] It has a sensitivity of 75% [70] and a specificity of 99.8%. [32] Common symptoms: [69] Raynaud's ...