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Prothrombin complex concentrate (PCC), also known as factor IX complex, sold under the brand name Kcentra among others, is a combination medication made up of blood clotting factors II, IX, and X [9] (3-factor PCC) or, when also containing factor VII as does Kcentra, 4-factor PCC. [10]
Treatment of established bleeding depends on the location but includes vitamin K 1 (phylloquinone; phytomenadione; phytonadione) administration which restores the prothrombin time rapidly. Severe bleeding may require blood products such as fresh frozen plasma (FFP), a prothrombin complex concentrate (PCC). [2]
[26] [28] In situations where rapid reversal is necessary for those on warfarin, such as in the case of major hemorrhage or surgery, 4-factor prothrombin complex concentrate (4F-PCC) is used with vitamin K to neutralize the effects of VKAs.
There are several treatments available for bleeding due to factor X deficiency. A specific FX concentrate was not available as of 2009. [4] Prothrombin complex concentrate (PCC) supplies FX with a risk of thrombosis. Fresh frozen plasma (FFP): This is relatively inexpensive and readily available. While effective this treatment carries a risk of ...
However, in urgent settings or settings with extremely high INR (INR >20), hemostatic reversal agents such as fresh frozen plasma (FFP), recombinant factor VIIa, and prothrombin complex concentrate (PCC) have been utilized with proven efficacy. [115]
Prothrombin complex concentrate and fresh frozen plasma are prothrombin-rich coagulation factor preparations that can be used to correct deficiencies (usually due to medication) of prothrombin. Indications include intractable bleeding due to warfarin. Manipulation of prothrombin is central to the mode of action of most anticoagulants.
Prothrombin complex concentrate (PCC) containing factor VII: this treatment is suitable for surgery, but has a risk of thrombosis. It is virus attenuated. It is virus attenuated. Fresh frozen plasma (FFP): This is relatively inexpensive and readily available.
Prothrombin complex concentrate, a medication; ... Puyi language (an ISO 639-3 language code: pcc) See also. Philippine Collegiate Champions League (PCCL)