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Functional neuroimaging has demonstrated hyperactivity of various brain regions in response to negative emotional stimuli, and hypoactivity in response to positive stimuli. One meta analysis reported that depressed subjects showed decreased activity in the left dorsolateral prefrontal cortex and increased activity in the amygdala in response to ...
Conversely, positive affect, the tendency to react positively and to maintain high energy levels and high amounts of positive emotion, may serve as a buffer against depression. Additionally, the tendency to make negative internal attributions predisposes individuals to the development of hopelessness and depression.
Social predictors of depression are aspects of one's social environment that are related to an individual developing major depression.These risk factors include negative social life events, conflict, and low levels of social support, all of which have been found affect the likelihood of someone experiencing major depression, the length of the depression, or the severity of the symptoms.
The neurogenesis hypothesis of depression posits that: [3] Stressful experiences have a negative effect on the process of neurogenesis in the subgranular zone of the dentate gyrus. Alternations in the rate of neurogenesis play a fundamental role in the pathology and treatment of major depression.
[7] [65] There is also initial evidence that major depression and stress can alter the permeability of the blood-brain barrier, allowing substances which would normally not be able to pass through enter the brain, thereby increasing the ways peripheral inflammation can affect the brain.
Emily Hollenbeck lived with a recurring depression she likened to a black hole, where gravity felt so strong and her limbs so heavy she could barely move. Researchers say the treatment — deep ...
Depression is an example of cognitive inhibition failure in emotion control. Correctly functioning cognitive inhibition would result in reduced selective attention to negative stimuli and retention of negative thoughts. "There is emerging evidence that depression is characterized by deficits in the inhibition of mood-congruent material.
It is a term adopted by an influential group of pharmaceutical executives and academic scientists to describe potentially fatal bleeding and swelling in the brain caused by drugs like Leqembi.
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