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Coal tar is available as a generic medication and over the counter. [4] Side effects include skin irritation, sun sensitivity, allergic reactions, and skin discoloration. [5] It is unclear if use during pregnancy is safe for the baby and use during breastfeeding is not typically recommended. [11] The exact mechanism of action is unknown. [12]
Seirogan (Japanese: 正露丸, formerly 征露丸) is a pharmaceutical drug marketed in Japan as a treatment for the digestive tract (especially as an antidiarrhoeal), whose main active ingredient is "wood creosote" (also wood-tar creosote, or beechwood creosote [1]).
The term creosote has a broad range of definitions depending on the origin of the coal tar oil and end-use of the material. With respect to wood preservatives, the United States Environmental Protection Agency (EPA) considers the term creosote to mean a pesticide for use as a wood preservative meeting the American Wood Protection Association (AWPA) Standards P1/P13 and P2. [6]
Goeckerman regimens use crude coal tar, which contains polycyclic aromatic hydrocarbon, a carcinogen. [8] [9] However, Goeckerman therapy is considered safe although use of tar may have the side-effects of contact dermatitis and mild local burning due to tar hypersensitivity.
Coal tar creosote; Wood creosote; Reduction product of vanillin using zinc powder in strong hydrochloric acid (Clemmensen reduction) Found as glycosides in green vanilla beans [2] It is also found in tequila. [3]
In 1849, Charles Blachford Mansfield rectified coal tar and identified fractions which he hypothesized to be cumole and cymole. The latter fraction boiled slightly above 170°C and had specific density of 0.857. [3] In 1862, Warren De la Rue and Hugo Müller (1833-1915) proposed the term pseudocumole for the fractions heavier than xylole. [4]
The residue remaining in the autoclave vessel is a dark, syrupy mass called creosote, which is composed mainly of phenolic acid and cresylic acid. The original composition of creolin is a creosote tar oil, caustic soda, soaps, and very little water. It is of low technology and a very powerful disinfectant. [1]
Phototoxic tar dermatitis results from coal tar, creosote, crude coal tar, or pitch, in conjunction with sunlight exposure, which induces a sunburn reaction associated with severe burning sensation. [ 1 ] : 32