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All three TGFβ1, TGFβ2 and TGFβ3. are synthesized as precursor molecules containing a propeptide region in addition to the TGF-β homodimer. [10] After it is synthesized, the TGF-β homodimer interact with a Latency Associated Peptide (LAP)[a protein derived from the N-terminal region of the TGF beta gene product] forming a complex called Small Latent Complex (SLC).
The latent TGF-beta binding proteins (LTBP) are a family of carrier proteins. [1] [2]LTBP is a family of secreted multidomain proteins that were originally identified by their association with the latent form of transforming growth factors.
All three TGF-βs are synthesized as precursor molecules containing a propeptide region in addition to the TGF-β homodimer. [20] After it is synthesized, the TGF-β homodimer interacts with a Latency-Associated Peptide (LAP), a protein derived from the N-terminal region of the TGF-β gene product, forming a complex called Small Latent Complex (SLC).
Latent-transforming growth factor beta-binding protein 1 is a protein that in humans is encoded by the LTBP1 gene. [ 5 ] [ 6 ] [ 7 ] The protein encoded by this gene belongs to the family of latent TGF-beta binding proteins (LTBPs).
Latent-transforming growth factor beta-binding protein 2 is a protein that in humans is encoded by the LTBP2 gene. [5] [6]The protein encoded by this gene belongs to the family of latent transforming growth factor (TGF)-beta binding proteins (LTBP), which are extracellular matrix proteins with multi-domain structure.
αvβ6-Integrin, the biological target of 68 Ga-Trivehexin, is a heterodimeric transmembrane cell adhesion receptor whose primary natural ligand is latency associated peptide (LAP) [2] in its complex with transforming growth factor beta 1 (TGF-β1). [3] Binding of αvβ6-integrin to LAP releases [4] and thus, activates [5] TGF-β1.
Transforming growth factor beta 1 or TGF-β1 is a polypeptide member of the transforming growth factor beta superfamily of cytokines. It is a secreted protein that performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation, and apoptosis. In humans, TGF-β1 is encoded by the TGFB1 gene. [5] [6]
Transforming growth factor-beta (TGF-beta) [6] is a multifunctional peptide that controls proliferation, differentiation and other functions in many cell types. TGF-beta-1 is a peptide of 112 amino acid residues derived by proteolytic cleavage from the C-terminal of a precursor protein.