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All three TGFβ1, TGFβ2 and TGFβ3. are synthesized as precursor molecules containing a propeptide region in addition to the TGF-β homodimer. [10] After it is synthesized, the TGF-β homodimer interact with a Latency Associated Peptide (LAP)[a protein derived from the N-terminal region of the TGF beta gene product] forming a complex called Small Latent Complex (SLC).
Because MMP-2 and MMP-9 can activate TGF-β through proteolytic degradation of the latent TGF beta complex, [31] αV containing integrins activate TGF-β1 by creating a close connection between the latent TGF-β complex and MMPs. Integrins αVβ6 and αVβ3 are suggested to simultaneously bind the latent TGF-β1 complex and proteinases ...
The secretion and activation of TGF-betas is regulated by their association with latency-associated proteins and with latent TGF-beta binding proteins. The product of this gene targets latent complexes of transforming growth factor beta to the extracellular matrix, where the latent cytokine is subsequently activated by several different mechanisms.
The latent TGF-beta binding proteins (LTBP) are a family of carrier proteins. [ 1 ] [ 2 ] LTBP is a family of secreted multidomain proteins that were originally identified by their association with the latent form of transforming growth factors .
Latent-transforming growth factor beta-binding protein 2 is a protein that in humans is encoded by the LTBP2 gene. [5] [6]The protein encoded by this gene belongs to the family of latent transforming growth factor (TGF)-beta binding proteins (LTBP), which are extracellular matrix proteins with multi-domain structure.
The principal function of αvβ6 is the activation of cytokine transforming growth factor-b1 (TGF-β1). [19] [29] Latent-TGF-β1 is bound to the extracellular matrix, covered by its pro-peptide latency associated peptide (LAP). [29] αvβ6 binds LAP, and through cytoskeletal force releases TGF-β1. [30]
21803 Ensembl ENSG00000105329 ENSMUSG00000002603 UniProt P01137 P04202 RefSeq (mRNA) NM_000660 NM_011577 RefSeq (protein) NP_000651 NP_035707 Location (UCSC) Chr 19: 41.3 – 41.35 Mb Chr 7: 25.39 – 25.4 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Transforming growth factor beta 1 or TGF-β1 is a polypeptide member of the transforming growth factor beta superfamily of cytokines ...
16998 Ensembl ENSG00000168056 ENSMUSG00000024940 UniProt Q9NS15 Q61810 RefSeq (mRNA) NM_001130144 NM_001164266 NM_021070 NM_008520 RefSeq (protein) NP_001123616 NP_001157738 NP_066548 NP_032546 Location (UCSC) Chr 11: 65.54 – 65.56 Mb Chr 19: 5.79 – 5.81 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Latent-transforming growth factor beta-binding protein 3 is a protein that in ...