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The test is largely archaic. Copper(I) thiocyanate is a reagent for the conversion of aryl diazonium salts to arylthiocyanates, a version of the Sandmeyer reaction. Since thiocyanate occurs naturally, it is to be expected that it serves as a substrate for enzymes. Two metalloenzymes, thiocyanate hydrolases, catalyze the hydrolysis of thiocyanate.
[7] [8] [9] Thus the complete absence of thiocyanate or reduced thiocyanate [10] in the human body, (e.g., cystic fibrosis) is damaging to the human host defense system. [11] [12] Thiocyanate is a potent competitive inhibitor of the thyroid sodium-iodide symporter. [13] Iodine is an essential component of thyroxine. Since thiocyanates will ...
Aryl thiocyanates are traditionally produced by the Sandmeyer reaction, which involves combining copper(I) thiocyanate and diazonium salts: [3] [ArN 2]BF 4 + CuSCN → ArSCN + CuBF 4 + N 2. Some arylthiocyanates can also often be obtained by thiocyanogenation, i.e. the reaction of thiocyanogen. This reaction is favored for electron-rich ...
This behavior is visualized by the color change brought about by reaction with thiocyanate: [Fe(H 2 O) 6] 3+ + SCN − ⇌ [Fe(SCN)(H 2 O) 5] 2+ + H 2 O. Whereas [Fe(H 2 O) 6] 3+ is nearly colorless, [Fe(SCN)(H 2 O) 5] 2+ is deep red. While iron(III) aquo complexes tend to convert to polymeric oxy-hydroxides, iron(III) complexes with other ...
The mixed reactants are delivered into an observation cell (flow cell) where the reaction can be monitored spectrophotometrically, typically using techniques such as absorbance, fluorescence, fluorescence anisotropy, or circular dichroism. It is increasingly common to combine several of these techniques for more comprehensive analysis. [6]
The free radicals generated by this process engage in secondary reactions. For example, the hydroxyl is a powerful, non-selective oxidant. [6] Oxidation of an organic compound by Fenton's reagent is rapid and exothermic and results in the oxidation of contaminants to primarily carbon dioxide and water.
A thiocyanate hydrolase (EC 3.5.5.8) is an enzyme belonging to the family of hydrolases. The systematic name of this enzyme class is thiocyanate aminohydrolase. This enzyme catalyzes the chemical reaction: SCN − + 2 H 2 O + H + ⇌ SCO + NH 3. The mechanism is proposed to involve a metal thiocyanate complex.
Thiocyanogen, (SCN) 2, is a pseudohalogen derived from the pseudohalide thiocyanate, [SCN] −, with behavior intermediate between dibromine and diiodine. [2] This hexatomic compound exhibits C 2 point group symmetry and has the connectivity NCS-SCN. [3] In the lungs, lactoperoxidase may oxidize thiocyanate to thiocyanogen [4] or ...