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2,4-Dinitrophenol (2,4-DNP or simply DNP) is an organic compound with the formula HOC 6 H 3 (NO 2) 2. It has been used in explosives manufacturing and as a pesticide and herbicide. In humans, DNP causes dose-dependent mitochondrial uncoupling , causing the rapid loss of ATP as heat and leading to uncontrolled hyperthermia —up to 44 °C (111 ...
2,4-Dinitrophenol (DNP) is a very strong thermogenic drug used for fat loss which produces a dose-dependent increase in body temperature, to the point where it can induce death by hyperthermia. It works as a mitochondrial oxidative phosphorylation uncoupler, disrupting the mitochondrial electron transport chain .
This takes place on a time scale of a few weeks. In the human body it is converted to 2,4-dinitrophenol. [8] Recent reports, demonstrated that a Nocardia sp. bacterium was able to mineralize 2, 4-dinitroanisole as a sole carbon source, via well established 2,4-dinitrophenol pathway. [9]
There are six isomers of dinitrophenol: Chemical structure of 2,4-Dinitrophenol. 2,3-Dinitrophenol; 2,4-Dinitrophenol; 2,5-Dinitrophenol; 2,6-Dinitrophenol; 3,4-Dinitrophenol; 3,5-Dinitrophenol; Dinitrophenols also form the core structure of some herbicides, which are collectively referred to as dinitrophenol herbicides, including: Chemical ...
It had a modest effect but produced the symptoms of hyperthyroidism as a side effect, such as palpitations and difficulty sleeping. [36] 2,4-Dinitrophenol (DNP) was introduced in 1933; this worked by uncoupling the biological process of oxidative phosphorylation in mitochondria, causing them to produce heat instead of ATP.
Dinoseb is a common industry name for 6-sec-butyl-2,4-dinitrophenol, a herbicide in the dinitrophenol family. It is a crystalline orange solid which does not readily dissolve in water. Dinoseb is banned as an herbicide in the European Union (EU) and the United States because of its toxicity.
2,4-DNP can mean: 2,4-Dinitrophenol , a small organic molecule formerly marketed as a pharmaceutical "diet aid" 2,4-Dinitrophenylhydrazine , Brady's reagent, used in organic chemical analysis
Being an analog of morphine, it would be expected to have the same effects on the body as a typical opioid. Also, as dinitrophenol is a metabolic and respiratory stimulant, this morphine derivative was invented in Austria in 1931 as a narcotic analgesic with less potential to depress respiration. [3]