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Right: (R)-(+)-thalidomide. Thalidomide is racemic; while S-thalidomide is the bioactive form of the molecule, the individual enantiomers can racemize to each other due to the acidic hydrogen at the chiral centre, which is the carbon of the glutarimide ring bonded to the phthalimide substituent. The racemization process can occur in vivo.
Phocomelia is a congenital condition that involves malformations of human arms and legs which result in a flipper-like appendage. [1] [2] A prominent cause of phocomelia is the mother being prescribed the use of the drug thalidomide during pregnancy; however, the causes of most cases are to be determined.
The underside of G. marginata – note the two pairs of legs per body segment. Glomeris marginata grows up to 20 millimetres (0.8 in) long and 8 mm (0.3 in) wide, and is covered by twelve black dorsal plates with white rims. [5] [6] Each segment except those at the front and back bears two pairs of legs, with around 18 pairs in total. [5]
As an indication of its value, it is noted that during the 1940s, army commander Wu Xuexian was seriously injured in his right leg. The French hospital in Kunming (capital of Yunnan) recommended amputation to save Wu's life. Wu turned to Qu for help, and to everyone's surprise, recovered without the need for an amputation.
A pill was originally defined as a small, round, solid pharmaceutical oral dosage form of medication. The word's etymology reflects the historical concepts of grinding the ingredients with a mortar and pestle and rolling the resultant paste or dough into lumps to be dried.
It is a pronation–supination tremor that is described as "pill-rolling"; that is, the index finger of the hand tends to get into contact with the thumb, and they perform a circular movement together. [1] [2] Such term was given due to the similarity of the movement in PD patients with the former pharmaceutical technique of manually making ...
Easton starts to look a little worn down, and his schedule changes in ways which make it harder to catch up with him.His hours of availability generally creep later than I, as a parent and working ...
The result is edema, pain and a white appearance (alba) of the leg. The next step in the disease progression is occlusion of the superficial venous system, thereby preventing all venous outflow from the extremity. At this stage it is called phlegmasia cerulea dolens. The leg becomes more swollen and increasingly more painful.
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