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Desmoid-type fibromatosis, also termed desmoid tumor and aggressive fibromatosis [26] Lipofibromatosis, a mixture of lipofibromatosis tumors with different gene abnormalities; [27] these tumors differ from lipofibromatosis-like neural tumors which have not been classified as fibroblastic and myofibroblastic tumors. Giant cell fibroblastoma [28]
Breast MFB has also been reported to develop at a surgical scar left after treatment for breast cancer and in patients with a history of prostate, kidney, and pancreatic cancer. [14] This tumor typically presents as a single, firm, mobile, painless mass; presentation as multiple masses is extremely rare. [14]
Inflammatory myofibroblastic tumor was initially regarded as a benign tumor that most often developed in the lung and less commonly in almost any organ system or tissue. Over time, however, IMT cases occurred in which the tumor spread into local tissues, metastasized to distal tissues, recurred after treatment, or consisted of neoplastic cells ...
For patients with a limb tumor that cannot be resected (less than 5% of all cases)), limb amputation is the treatment of choice. [7] Recurrent and metastatic MFS first-line treatment has employed two chemotherapy drugs, anthracycline and Ifosfamide , while second-line treatment has employed two other chemotherapy drugs, gemcitabine and ...
A cancer-associated fibroblast (CAF) (also known as tumour-associated fibroblast; carcinogenic-associated fibroblast; activated fibroblast) is a cell type within the tumor microenvironment that promotes tumorigenic features by initiating the remodelling of the extracellular matrix or by secreting cytokines.
Undifferentiated pleomorphic sarcoma (UPS), also termed pleomorphic myofibrosarcoma, [1] high-grade myofibroblastic sarcoma, and high-grade myofibrosarcoma, [2] is characterized by the World Health Organization (WHO) as a rare, poorly differentiated neoplasm (i.e., an abnormal growth of cells that have an unclear identity and/or cell of origin). [3]
Pseudoangiomatous stromal hyperplasia (PASH) is an overgrowth of myofibroblastic cells in the breast. It has an appearance similar to fibroadenomatoid changes. [1] The diagnostic significance is currently uncertain, but it appears to be benign. There have been cases of PASH diagnosed where the tumors co-exist with breast cancer.
Desmoid tumors of the breast are rare, constituting 4% of extra-abdominal cases and 0.2–0.3% of breast tumors. [27] [24] Although benign, they can mimic breast cancer on physical examination, mammography and breast ultrasound and can also be locally invasive. Even though they occur sporadically, they can also be seen as a part of Gardner's ...