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This is a list of 5α-reductase inhibitors (5α-RIs), drugs which inhibit one or more isoforms of the enzyme 5α-reductase.This enzyme is responsible for the conversion of the androgen hormone testosterone into the more potent dihydrotestosterone (DHT) and is essential for the production of neurosteroids like allopregnanolone, tetrahydrodeoxycorticosterone (THDOC), and 3α-androstanediol from ...
Side effects of androstanolone include symptoms of masculinization like acne, increased hair growth, voice changes, and increased sexual desire. [2] The medication is a naturally occurring androgen and anabolic steroid and hence is an agonist of the androgen receptor (AR), the biological target of androgens like testosterone and DHT.
In BPH, DHT acts as a potent cellular androgen and promotes prostate growth; therefore, DHT blockers inhibit and alleviate symptoms of BPH. In alopecia, male and female-pattern baldness is an effect of androgenic receptor activation, so reducing levels of DHT also reduces hair loss.
Other 5α-reductase inhibitors such as finasteride (a type 2 inhibitor) have been used off-label to treat excessive hair growth in women with hirsutism. [3] [23] Since dutasteride is an inhibitor of both type 1 and 2 5α-reductases, it could theoretically be a more effective therapy for hirsutism. However, dutasteride is not recommended for ...
Blu Atlas Shampoo is made with the best hair growth ingredients. For example, saw palmetto is rich in anti-inflammatory properties that are known to counter DHT—a hormone that is understood to ...
Saw palmetto (or Serenoa repens) – a type of palm tree found growing in the southeastern United States. Its extract has been promoted as a prostate cancer medicine; however, according to the American Cancer Society, "available scientific studies do not support claims that saw palmetto can prevent or treat prostate cancer in humans". [100]
This included a greatly increased risk of breast pain (RR = 22.97) and gynecomastia (RR = 8.43). [122] The risk of other adverse effects, such as hot flashes (RR = 0.23), was decreased with NSAA monotherapy. [122] The quality of the evidence was deemed moderate. [122]
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