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Upstream extracellular signaling transduce a variety of intracellular cascades. [1] Receptors and ligands are common upstream signaling molecules that dictate the downstream elements of the signal pathway. A plethora of different factors affect which ligands bind to which receptors and the downstream cellular response that they initiate.
The oil and gas industry is usually divided into three major sectors: upstream (also called exploration and production or E&P), midstream and downstream. [1] [2] The upstream sector includes searching for potential underground or underwater crude oil and natural gas fields, drilling exploratory wells, and subsequently operating the wells that recover and bring the crude oil or raw natural gas ...
Vertical integration is the degree to which a firm owns its upstream suppliers and its downstream buyers. The differences depend on where the firm is placed in the order of the supply chain. There are three varieties of vertical integration: backward (upstream) vertical integration, forward (downstream) vertical integration, and balanced (both ...
There are a variety of supply-chain models, which address both the upstream and downstream elements of supply-chain management (SCM). The SCOR ( Supply-Chain Operations Reference ) model, developed by a consortium of industry and the non-profit Supply Chain Council (now part of APICS ) became the cross-industry de facto standard defining the ...
Barrage dams control the amount of water going through them, leading to differences in the amount of water upstream and downstream from the dam. This discrepancy has different effects on different species native to the area. While there can be reduced flow downstream, there can also be problems upstream.
By damming a river, the head is available to generate power at the face of the dam. A dam may create a reservoir hundreds of kilometres long, but in run-of-the-river the head is usually delivered by a canal, pipe or tunnel constructed upstream of the power house. The cost of upstream construction makes a steep drop desirable, such as falls or ...
The oil and gas industry is usually divided into three major sectors: upstream, midstream, and downstream. The downstream sector is the refining of petroleum crude oil and the processing and purifying of raw natural gas, [1] as well as the marketing and distribution of products derived from crude oil and natural gas.
The impact factor relates to a specific time period; it is possible to calculate it for any desired period. For example, the JCR also includes a five-year impact factor, which is calculated by dividing the number of citations to the journal in a given year by the number of articles published in that journal in the previous five years. [14] [15]