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Ideally, the oxygen provided via ventilation would be just enough to saturate the blood fully. In the typical adult, 1 litre of blood can hold about 200 mL of oxygen; 1 litre of dry air has about 210 mL of oxygen. Therefore, under these conditions, the ideal ventilation perfusion ratio would be about 0.95.
The ratio of partial pressure arterial oxygen and fraction of inspired oxygen, known as the Horowitz index or Carrico index, is a comparison between the oxygen level in the blood and the oxygen concentration that is breathed. This helps to determine the degree of any problems with how the lungs transfer oxygen to the blood. [5]
The respiratory exchange ratio (RER) is the ratio between the metabolic production of carbon dioxide (CO 2) and the uptake of oxygen (O 2). [3] [4] The ratio is determined by comparing exhaled gases to room air. Measuring this ratio is equal to RQ only at rest or during mild to moderate aerobic exercise without the accumulation of lactate.
Lung volumes and lung capacities refer to the volume of air in the lungs at different phases of the respiratory cycle. The average total lung capacity of an adult human male is about 6 litres of air. [1] Tidal breathing is normal, resting breathing; the tidal volume is the volume of air that is inhaled or exhaled in only a single such breath.
During the test the person inhales a test gas mixture that consisting of regular air that includes an inert tracer gas and CO, less than one percent. Since hemoglobin has a greater affinity to CO than oxygen the breath-hold time can be only 10 seconds, which is a sufficient amount of time for this transfer of CO to occur.
The increased lung pressure pushes the air out of the lungs. [2] The primary function of ventilation is the replacement of the stale gases in the lungs with oxygen-rich air through the removal of carbon dioxide for oxygenation of the blood. [5] The oxygen is then supplied to the entire body through the circulatory system.
The alveolar oxygen partial pressure is lower than the atmospheric O 2 partial pressure for two reasons. Firstly, as the air enters the lungs, it is humidified by the upper airway and thus the partial pressure of water vapour (47 mmHg) reduces the oxygen partial pressure to about 150 mmHg.
For humans, the typical respiratory rate for a healthy adult at rest is 12–15 breaths per minute. [10] The respiratory center sets the quiet respiratory rhythm at around two seconds for an inhalation and three seconds exhalation. This gives the lower of the average rate at 12 breaths per minute.
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