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Chemical structure of fosfomycin. Fosfomycin is a phosphonic acid bactericidal agent. It is commonly used as the first-line treatment for acute simple cystitis, demonstrating a 91% cure rate. [4] [9] It is administered orally as a single dose; In more complicated UTIs, the dose is adjusted to be repeated every three days to achieve successful ...
A single dose when breastfeeding appears safe. [9] Fosfomycin works by interfering with the production of the bacterial cell wall. [8] Fosfomycin was discovered in 1969 and approved for medical use in the United States in 1996 [globalize] [8] [10] It is on the World Health Organization's List of Essential Medicines. [11]
A urinary tract infection ... Escherichia coli is the single most common microorganism, ... Fosfomycin may be used as a single dose but is not as effective.
Fosfomycin can be used as an efficacious treatment for both UTIs and complicated UTIs including acute pyelonephritis. The standard regimen for complicated UTIs is an oral 3g dose administered once every 48 or 72 hours for a total of 3 doses or a 6 grams every 8 hours for 7 days to 14 days when fosfomycin is given in IV form. [32]
[15] [25] [21] The effectiveness of nitrofurantoin for 5 days is equivalent to that with single-dose fosfomycin. [26] As a prophylactic against UTIs, nitrofurantoin was similarly effective to other antibiotics, with a UTI risk ratio of 0.38.
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