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54519 Ensembl ENSG00000077420 ENSMUSG00000026786 UniProt Q7Z5R6 Q8R5A3 RefSeq (mRNA) NM_019043 NM_019456 RefSeq (protein) NP_061916 NP_062329 Location (UCSC) Chr 10: 26.44 – 26.57 Mb Chr 2: 22.66 – 22.77 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Amyloid beta A4 precursor protein-binding family B member 1-interacting protein (APBB1IP), also known as APBB1-interacting protein ...
Alzheimer's disease (AD) is a progressive neurodegenerative condition that gradually destroys the abilities to remember, reason, and engage in meaningful social interaction. AD caregivers report that most of their stress comes from unsuccessful attempts to communicate with their patients.
The autonomous device, which is also built to support the elderly, helps its owner interact with smart home environment as well as caregivers. The robot functions as a mobile friend, by which natural interaction is possible via speech and the touchscreen to detect and track people at home. [11] [12] [10]
Researchers project the number of people with Alzheimer’s disease will increase to 153 million by 2050. Scientists are focused on identifying health conditions and diseases that may increase a ...
Alzheimer's disease is the most common form of dementia, and studies have shown that manipulation of pathways involving LRP8/ApoER2 can lead to the disease. Certain alleles, such as apoe, app, ps1 and ps2, may lead to being genetically predisposed to the disease. [13] A decrease in LRP8 expression is observed in patients with Alzheimer's disease.
A different perspective on Alzheimer's is revealed by a mouse study that has found that APP possesses ferroxidase activity similar to ceruloplasmin, facilitating iron export through interaction with ferroportin; it seems that this activity is blocked by zinc trapped by accumulated Aβ in Alzheimer's. [9]
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People with dementia are more likely to have problems with incontinence; they are three times more likely to have urinary and four times more likely to have fecal incontinence compared to people of similar ages. [62] [63] This can have a profound impact on the dignity and quality of life of people with dementia and their caregivers. [62] [64]
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