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Loop diuretics are pharmacological agents that primarily inhibit the Na-K-Cl cotransporter located on the luminal membrane of cells along the thick ascending limb of the loop of Henle. [4] They are often used for the treatment of hypertension and edema secondary to congestive heart failure , liver cirrhosis , or chronic kidney disease .
Hydrochlorothiazide, sold under the brand name Hydrodiuril among others, is a diuretic medication used to treat hypertension and swelling due to fluid build-up. [4] Other uses include treating diabetes insipidus and renal tubular acidosis and to decrease the risk of kidney stones in those with a high calcium level in the urine. [4]
Thiazide diuretics also increase calcium reabsorption at the distal tubule. By lowering the sodium concentration in the tubule epithelial cells, thiazides indirectly increase the activity of the basolateral Na + /Ca 2+ antiporter to maintain intracellular Na + level, facilitating Ca 2+ to leave the epithelial cells into the renal interstitium.
The U.S Capitol is seen after U.S, President-elect Donald Trump called on U.S. lawmakers to reject a stopgap bill to keep the government funded past Friday, raising the likelihood of a partial ...
Simon Petrén is the producer as well as mix/mastering engineer for the YouTube phenomena Dirty Loops. Their debut album was released by David Foster and Verve Records/Universal Music, USA/Japan (May 19, 2014). [1] As of 2019 they are managed by Quincy Jones. [2]
Pro wrestling great Jeff Hardy said in an interview on Tuesday he thinks he could have been bigger than John Cena if he was doing the things he is doing now earlier in his career.
My husband and I separated, and I moved into an apartment near our family home. We wanted to prioritize keeping things stable for our three children.
A thiazide-like diuretic is a sulfonamide diuretic that has similar physiological properties to a thiazide diuretic, but does not have the chemical properties of a thiazide, lacking the benzothiadiazine molecular structure. Examples include metolazone, chlorthalidone, and indapamide. [1]