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The human stratum corneum comprises several levels of flattened corneocytes that are divided into two layers: the stratum disjunctum and stratum compactum. The skin's protective acid mantle and lipid barrier sit on top of the stratum disjunctum. [5] The stratum disjunctum is the uppermost and loosest layer of skin.
The epidermis is the outermost of the three layers that comprise the skin, the inner layers being the dermis and hypodermis. [1] The epidermis layer provides a barrier to infection from environmental pathogens [2] and regulates the amount of water released from the body into the atmosphere through transepidermal water loss.
As a result of the weakened corneodesmosomes in the outer skin surface, the uppermost layers of corneocytes get exfoliated through frictional forces such as rubbing or washing. This process is a normal protective mechanism of the skin to prevent pathogens from colonizing the skin, and is referred to as desquamation. In healthy skin ...
The human skin is the outer covering of the body and is the largest organ of the integumentary system. The skin has up to seven layers of ectodermal tissue guarding muscles, bones, ligaments and internal organs. Human skin is similar to most of the other mammals' skin, and it is very similar to pig skin.
Keratinocytes form tight junctions with the nerves of the skin and hold the Langerhans cells and intra-dermal lymphocytes in position within the epidermis. Keratinocytes also modulate the immune system : apart from the above-mentioned antimicrobial peptides and chemokines they are also potent producers of anti-inflammatory mediators such as IL ...
The skin is one of the largest organs of the body. In humans, it accounts for about 12 to 15 percent of total body weight and covers 1.5 to 2 m 2 of surface area. [1] 3D still showing human integumentary system. The skin (integument) is a composite organ, made up of at least two major layers of tissue: the epidermis and the dermis. [2]
Melanin is a chromophore that exists in the human epidermal layer of skin responsible for protection from harmful UV radiation. When melanocytes are stimulated by solar radiation, melanin is produced. [7] Melanin is one of the major absorbers of light in some biological tissue (although its contribution is smaller than other components).
Others serve to anchor the epidermis glabrous skin (hairless), and hyper-proliferative epidermis (from a skin disease). [1] They divide to form the keratinocytes of the stratum spinosum, which migrate superficially. [2] Other types of cells found within the stratum basale are melanocytes (pigment-producing cells) and Merkel cells (touch receptors).