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Lipinski's rule of five, also known as Pfizer's rule of five or simply the rule of five (RO5), is a rule of thumb to evaluate druglikeness or determine if a chemical compound with a certain pharmacological or biological activity has chemical properties and physical properties that would likely make it an orally active drug in humans.
The study has been criticized for not having a generalizable sample. [1]: 11 [31] Moreover, Terman meddled in his subjects' lives, giving them letters of recommendation for jobs and college and pulling strings at Stanford to help them get admitted. [2] [22] This makes the life outcomes of the sample biased and difficult to generalize. [2]
The GRADE approach separates recommendations following from an evaluation of the evidence as strong or weak. A recommendation to use, or not use an option (e.g. an intervention), should be based on the trade-offs between desirable consequences of following a recommendation on the one hand, and undesirable consequences on the other.
A "one in 20 rule" has been suggested, indicating the need for shrinkage of regression coefficients, and a "one in 50 rule" for stepwise selection with the default p-value of 5%. [ 4 ] [ 6 ] Other studies, however, show that the one in ten rule may be too conservative as a general recommendation and that five to nine events per predictor can be ...
A systematic review focuses on a specific research question to identify, appraise, select, and synthesize all high-quality research evidence and arguments relevant to that question. A meta-analysis is typically a systematic review using statistical methods to effectively combine the data used on all selected studies to produce a more reliable ...
The main conclusions and recommendations (i.e., how the work answers the proposed research problem). It may also contain brief references, [ 20 ] although some publications' standard style omits references from the abstract, reserving them for the article body (which, by definition, treats the same topics but in more depth).
Research and recommendations Committees may be formed to do research and make recommendations on a potential or planned project or change. For example, an organization considering a major capital investment might create a temporary working committee of several people to review options and make recommendations to upper management or the board of ...
In survey research, the design effect is a number that shows how well a sample of people may represent a larger group of people for a specific measure of interest (such as the mean). This is important when the sample comes from a sampling method that is different than just picking people using a simple random sample.