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The cleavage model was first proposed in 1993 based on work done with Drosophila Notch and C. elegans lin-12, [16] [17] informed by the first oncogenic mutation affecting a human Notch gene. [18] Compelling evidence for this model was provided in 1998 by in vivo analysis in Drosophila by Gary Struhl [19] and in cell culture by Raphael Kopan. [20]
In cell biology, a biological pathway is a series of interactions among molecules in a cell that leads to a certain product or a change in the cell. Such a pathway can trigger the assembly of new molecules, such as a fat or protein. Pathways can also turn genes on and off, or spur a cell to move. [1]
Definition [ edit ] The word pedigree is a corruption of the Anglo-Norman French pé de grue or "crane's foot", either because the typical lines and split lines (each split leading to different offspring of the one parent line) resemble the thin leg and foot of a crane [ 3 ] or because such a mark was used to denote succession in pedigree charts.
Pathway resources and types of pathway analysis using databases like KEGG, Reactome and WikiPathways. [1]Pathway is the term from molecular biology for a curated schematic representation of a well characterized segment of the molecular physiological machinery, such as a metabolic pathway describing an enzymatic process within a cell or tissue or a signaling pathway model representing a ...
An anabolic pathway is a biosynthetic pathway, meaning that it combines smaller molecules to form larger and more complex ones. [ 10 ] : 570 An example is the reversed pathway of glycolysis, otherwise known as gluconeogenesis , which occurs in the liver and sometimes in the kidney to maintain proper glucose concentration in the blood and supply ...
In this article, all values (except the ones listed below) denote blood plasma concentration, which is approximately 60–100% larger than the actual blood concentration if the amount inside red blood cells (RBCs) is negligible.
The G 1 phase, gap 1 phase, or growth 1 phase, is the first of four phases of the cell cycle that takes place in eukaryotic cell division. In this part of interphase, the cell synthesizes mRNA and proteins in preparation for subsequent steps leading to mitosis. G 1 phase ends when the cell moves into the S phase of interphase.
The original work of Wiener and Rosenblueth contains many insights and continues to be cited in modern research publications on cardiac arrhythmia and excitable systems. [ 19 ] In the 1960s, cellular automata were studied as a particular type of dynamical system and the connection with the mathematical field of symbolic dynamics was established ...