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It has been known for decades that the addition of cholesterol to a fluid phase bilayer decreases its permeability to water. [6] [7] The mode of this interaction has more recently been shown to be due to cholesterol intercalating between lipid molecules, filling in free space and decreasing the flexibility of surrounding lipid chains. [8]
In fluid mechanics, materials science and Earth sciences, the permeability of porous media (often, a rock or soil) is a measure of the ability for fluids (gas or liquid) to flow through the media; it is commonly symbolized as k. Fluids can more easily flow through a material with high permeability than one with low permeability. [1]
Most polar molecules have low solubility in the hydrocarbon core of a lipid bilayer and, as a consequence, have low permeability coefficients across the bilayer. This effect is particularly pronounced for charged species, which have even lower permeability coefficients than neutral polar molecules. [61]
Permeation will occur over time with the tires, so it is best to know the permeability of the material that will make up the tire with the desired gas to make the most efficient tires. Insulating material: Water vapour permeation of insulating material is important as well as for submarine cables to protect the conductor from corrosion.
The more cholesterol a rat eats the lower the blood cholesterol. [16] During the first seven hours after ingestion of cholesterol, as absorbed fats are being distributed around the body within extracellular water by the various lipoproteins (which transport all fats in the water outside cells), the concentrations increase.
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In fluid mechanics, fluid flow through porous media is the manner in which fluids behave when flowing through a porous medium, for example sponge or wood, or when filtering water using sand or another porous material. As commonly observed, some fluid flows through the media while some mass of the fluid is stored in the pores present in the media.
Cholesterol molecules are also found throughout the plasma membrane and act as a buffer of membrane fluidity. [3] The phospholipid bilayer is most permeable to small, uncharged solutes. Protein channels are embedded in or through the phospholipids, [4] and, collectively, this model is known as the fluid mosaic model.