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The predominant symptoms of NC involve one or both legs and usually presents as some combination of tingling, cramping discomfort, pain, numbness, or weakness in the lower back, calves, glutes, and thighs and is precipitated by walking and prolonged standing. However, the symptoms vary depending on the severity and cause of the condition.
Generally speaking, the muscular pain is steady, aching, and deep. Depending on the case and location the intensity can range from mild discomfort to excruciating and "lightning-like". Knots may be visible or felt beneath the skin. The pain does not resolve on its own, even after typical first-aid self-care such as ice, heat, and rest. [4]
Deep, non-localised pain not affected by movement suggests bone medulla involvement, with ischaemia due to blood vessel blockage and swelling inside the bone, which is mechanistically associated with osteonecrosis, and therefore it has been strongly recommended that these symptoms are treated with hyperbaric oxygen.
The results may range from pain in the joints where the bubbles form to blockage of an artery(air bubble) [4] leading to damage to the fatigue, joint and muscle pain, clouded thinking, numbness, weakness, paralysis, rash, poor muscle coordination or balance, paralysis or death. While bubbles can form anywhere in the body, DCS is most frequently ...
[12] [33]: 57 Finally, sleep disorders, coeliac disease, and side effects of medications may also explain symptoms. [12] Joint and muscle pain without swelling or inflammation is a common feature of ME/CFS, but is more closely associated with fibromyalgia. Modern definitions of fibromyalgia not only include widespread pain but also fatigue ...
Other common symptoms include excessive swelling that causes the skin to become hot, stretched and glossy. Pain, paresthesias, and tenderness in both the ischemic muscles and the region supplied by the deep common fibular nerve are exhibited by patients with this condition. Sensitivity to passive stretch and active contraction are common, and ...
An acute injury can be traced back to a specific incident, causing immediate pain and often swelling. [15] [16] On the other hand, a Chronic injury does not have a distinct origin, it develops slowly, is persistent and long lasting, and it is accompanied by dull pain, aches or soreness. [15] Broken Metacarpals from a high impact fall
The association of serotonin with mood and cognition may explain some of the side-effects observed in patients treated with L-Dopa due to serotonin deficit. [9] [10] In most cases, motor symptoms predominate at early PD stages, while cognitive disturbances (such as mild cognitive impairment or dementia) emerge later. [11]
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