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Buruli ulcer has been the subject of scientific research since the description of M. ulcerans in 1948, and the demonstration that the bacteria could cause ulcers in laboratory animals. [ 11 ] [ 54 ] While several animals are susceptible to M. ulcerans ulcers, mice (particularly BALB/c and C57BL/6 mice) are most commonly used to model Buruli ...
A 2004 WHO resolution "called for increasing surveillance and control, and for intensified research to develop tools to diagnose, treat and prevent" Buruli ulcer. [4] In 2009, a strategy to promote early detection and provide wider access to antibiotics was adopted. [6]
This grows larger over days to weeks, forming an open ulcer (biopsy images pictured). Deep ulcers can cause scarring of muscles and tendons, resulting in permanent disability. The World Health Organization (WHO) recommends treating Buruli ulcer with a combination of the antibiotics rifampicin and clarithromycin. Regular cleaning and dressing of ...
The bacteria can infect humans and some other animals, causing persistent open wounds called Buruli ulcer. M. ulcerans is closely related to Mycobacterium marinum , from which it evolved around one million years ago, and more distantly to the mycobacteria which cause tuberculosis and leprosy .
Deep ulcers can cause scarring of muscles and tendons, resulting in permanent disability. Buruli ulcer is caused by skin infection with bacteria called Mycobacterium ulcerans . The mechanism by which M. ulcerans is transmitted from the environment to humans is not known, but may involve the bite of an aquatic insect or the infection of open wounds.
Mycolactone is a polyketide-derived macrolide produced and secreted by a group of very closely related pathogenic mycobacteria species including M. ulcerans, M. liflandii (an unofficial designation), M. pseudoshottsii, and some strains of M. marinum.
Once developed, the ulcer may become chronic and stable, but also it can run a destructive course with deep tissue invasion, osteitis, and risk of amputation. Unlike Buruli ulcer, tropical ulcers are very painful. [4] Lesions begin with inflammatory papules that progress into vesicles and rupture with the formation of an ulcer. [1]
This file, which was originally posted to Ruf MT, Sopoh GE, Brun LV, Dossou AD, Barogui YT, et al. (2011) Histopathological Changes and Clinical Responses of Buruli Ulcer Plaque Lesions during Chemotherapy: A Role for Surgical Removal of Necrotic Tissue?. PLOS Neglected Tropical Diseases 5(9): e1334.