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The biology of depression is the attempt to identify a biochemical origin of depression, as opposed to theories that emphasize psychological or situational causes. Scientific studies have found that different brain areas show altered activity in humans with major depressive disorder (MDD) . [ 1 ]
Endogenous depression is an atypical subclass of major depressive disorder (clinical depression). It could be caused by genetic and biological factors. [ 1 ] Endogenous depression occurs due to the presence of an internal (cognitive, biological) stressor instead of an external (social, environmental) stressor. [ 2 ]
In the simplest example of the method, an equal volume of beads are added to a cell or tissue suspension in a test tube and the sample is vigorously mixed on a common laboratory vortex mixer. While processing times are slow, taking 3–10 times longer than that in specialty shaking machines , it works well for easily disrupted cells and is ...
Many professionals believe that the cause of mental disorders is the biology of the brain and the nervous system. [ citation needed ] Mind mentions genetic factors, long-term physical health conditions, and head injuries or epilepsy (affecting behavior and mood) as factors that may trigger an episode of mental illness.
This is seen in that immune activity does not appear to be enough on its own to cause depression. [39] Evidence for this comes primarily from treatments that involve the pro-inflammatory IFN-α, which is commonly used in treating viral infections but only results in major depression in about one third of patients.
Open field test, elevated plus maze test, and dark/light box test can work as an antidepressant screen by measuring anxiety-related behavior as an accompanying endophenotype of depression. It is known that some antidepressants will cause a decrease in behavior in these tests just like anxiolytics.
Major depression (also called "major depressive disorder", "clinical depression" or often simply "depression") is a leading cause of disability worldwide, and in 2000 was the fourth leading contributor to the global burden of disease (measured in DALYs); it is also an important risk factor for suicide. [1]
In physiology and medicine, depression [1] refers to a lowering, in particular a reduction in a specific biological variable or the functions of an organ. It is the opposite of elevation. For example, it is possible to refer to "depressed thyroid function" or to a depression of blood flow in a particular area. Further examples: