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Methylphosphonyl dichloride (DC) or dichloro is an organophosphorus compound. It has commercial application in oligonucleotide synthesis, [1] but is most notable as being a precursor to several chemical weapons agents. It is a white crystalline solid that melts slightly above room temperature. [2]
Although phosphonates are profoundly cell impermeable, natural product phosphonate antibiotics are effective against a number of organisms, because many bacterial species express glycerol-3-phosphate and glucose-6-phosphate importers, which can be hijacked by phosphonate antibiotics.
Methyldichlorophosphine is produced by alkylation of phosphorus trichloride with methyl iodide followed by reduction of the resulting phosphonium salt with iron powder: [2] [3]
It will react with thionyl chloride to produce methylphosphonic acid dichloride, which is used in the production of sarin and soman nerve agents. Various amines can be used to catalyse this process. [3] It can be used as a sarin-simulant for the calibration of organophosphorus detectors.
Methylphosphonic acid is an organophosphorus compound with the chemical formula CH 3 P(O)(OH) 2. The phosphorus center is tetrahedral and is bonded to a methyl group, two OH groups and an oxygen. Methylphosphonic acid is a white, non-volatile solid that is poorly soluble in organic solvent but soluble in water and common alcohols.
Dichlorobis(triphenylphosphine)nickel(II) refers to a pair of metal phosphine complexes with the formula NiCl 2 [P(C 6 H 5) 3] 2. The compound exists as two isomers, a paramagnetic dark blue solid and a diamagnetic red solid. These complexes function as catalysts for organic synthesis. [1]
Dimethylaminophosphorus dichloride is an organophosphorus compound with the formula Me 2 NPCl 2 (Me = methyl). A colorless liquid, it is a reagent in the preparation of other organophosphorus compounds. Many analogous compounds can be prepared from the reactions of secondary amines and phosphorus trichloride: [1] 2 R 2 NH + PCl 3 → R 2 NPCl 2 ...
Methylphosphonyl difluoride (DF), also known as EA-1251 [2] or difluoro, [3] is a chemical weapon precursor. Its chemical formula is CH 3 POF 2.It is a Schedule 1 substance under the Chemical Weapons Convention.