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The 5-HT 2A receptor is a subtype of the 5-HT 2 receptor that belongs to the serotonin receptor family and is a G protein-coupled receptor (GPCR). [4] The 5-HT 2A receptor is a cell surface receptor, [5] but has several intracellular locations. [6] Like all 5-HT 2 receptors, the 5-HT 2A receptor is G q /G 11-protein coupled.
DOB is a serotonin 5-HT 2A, 5-HT 2B, and 5-HT 2C receptor agonist. [5] [6] Its psychedelic effects are mediated by its agonistic properties at the 5-HT 2A receptor. Due to its selectivity, DOB is often used in scientific research when studying the 5-HT 2 receptor subfamily.
DOB-2-DRAGONFLY-5-BUTTERFLY is a drug with an unusual furo[2,3-g]chromene core structure which acts as a 5-HT 2A receptor agonist.It was first synthesised by David E. Nichols and colleagues in 2008, and while it is weaker than similar compounds such as Bromo-DragonFLY it is still the most potent among a number of related derivatives.
Dimethoxybromoamphetamine (DOB; brolamfetamine) – serotonin 5-HT 2A, 5-HT 2B, and 5-HT 2C receptor agonist and psychedelic hallucinogen – unknown – unknown [283] [284] Dimethoxyethylamphetamine (DOET) – serotonin 5-HT 2A , 5-HT 2B , and 5-HT 2C receptor agonist and psychedelic hallucinogen – unknown – Dow Chemical Company [ 285 ]
This is a list of miscellaneous agonists of the serotonin receptor subtype 5-HT 2A (and other 5-HT 2 subtypes to a varying extent) that fall outside the common structural classes.
4C-B (also known as 4C-DOB or DOB-B) is a lesser-known psychedelic drug which is related to 2C-B and DOB. [1] It is a reasonably potent 5-HT 2A receptor partial agonist with a K i of 7.6 nM, but has relatively low efficacy (15% relative to 5-HT). [2]
Its affinities for the serotonin 5-HT 2A and 5-HT 2C receptors in the study were approximately 8-fold and 1.6-fold higher than those of DOB, respectively. [1] The drug was a full agonist of the serotonin 5-HT 2A receptor in terms of phosphatidylinositol (PI) hydrolysis (E max Tooltip half-maximal effective concentration = 109% relative to ...
[3] [4] [6] In the case of the serotonin 5-HT 2A receptor, this was 6- to 14-fold higher than DOB, DOI, and DOC and was 9-fold higher than DOPR. [3] [6] In another study, DOHx showed 25-fold higher affinity for the serotonin 5-HT 2A receptor than DOM or DOET, 23- to 28-fold higher affinity than DOPR and DOBU, and 2.8-fold higher affinity than ...