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The first to investigate trifluoromethyl groups in relationship to biological activity was F. Lehmann in 1927. [5] An early review appeared in 1958. [6] An early synthetic method was developed by Frédéric Swarts in 1892, [7] based on antimony fluoride. In this reaction benzotrichloride was reacted with SbF 3 to form PhCF 2 Cl and PhCF 3.
Trifluoromethyl group covalently bonded to an R group. The trifluoromethyl group is a functional group that has the formula-CF 3. The naming of is group is derived from the methyl group (which has the formula -CH 3), by replacing each hydrogen atom by a fluorine atom. Some common examples are trifluoromethane H– CF 3, 1,1,1-trifluoroethane H ...
3-(Trifluoromethyl)aniline is an organic compound with the formula CF 3 C 6 H 4 NH 2. It is one of three isomers of trifluoromethylaniline. It is one of three isomers of trifluoromethylaniline. Classified as an aromatic amines , they are colorless liquids.
It is unclear why trifluralin's exotic 4-trifluoromethyl was tested so early (1960), before more common candidates such as fluoro, bromo, or iodo. [ 7 ] By 1968, trifluralin was internationally available, including Australia and New Zealand, [ 6 ] and trifluralin was the 5th most used herbicide in the US, at 22,960,000 pounds (10,410 t) by 1974.
4-Fluoroaniline can be prepared by the hydrogenation of 4-nitrofluorobenzene. [2] It is a common building block in medicinal chemistry and related fields. [3] For example, it is a precursor to the fungicide fluoroimide or the fentanyl analogue parafluorofentanyl. It has also been evaluated for the production of ligands for homogeneous catalysis ...
Like all primary and secondary perfluoroalcohols, trifluoromethanol eliminates hydrogen fluoride in an endothermic reaction [3] and forms carbonyl fluoride. [4] CF 3 OH ⇌ COF 2 + HF (I) At temperatures in the range of -120 °C, trifluoromethanol can be prepared from trifluoromethyl hypochlorite and hydrogen chloride: CF 3 OCl + HCl → CF 3 ...
Typically these reactions would be conducted in the presence of a base which serves to absorb the HCl. Alkyl chloroformate esters degrate to give the alkyl chloride, with retention of configuration: ROC(O)Cl ' → RCl + CO 2. The reaction is proposed to proceed via a substitution nucleophilic internal mechanism. [3]
A more dilute hydrogen peroxide solution (30%) can be used to form trifluoroperacetic acid for some reactions from trifluoroacetic acid. [2] CF 3 COOH + H 2 O 2 → CF 3 COOOH + H 2 O. In order to avoid the danger of handling pure or highly concentrated solutions of hydrogen peroxide, hydrogen peroxide – urea can be used to give the peracid. [5]