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The Dieckmann condensation is the intramolecular chemical reaction of diesters with base to give β-keto esters. [1] It is named after the German chemist Walter Dieckmann (1869–1925). [2] [3] The equivalent intermolecular reaction is the Claisen condensation. Dieckmann condensations are highly effective routes to 5-, 6-, and 7-member rings ...
The following other wikis use this file: Usage on ar.wikipedia.org تفاعل تكاثف; Usage on ca.wikipedia.org Compost cíclic; Usage on es.wikipedia.org
Acyloin condensation is a reductive coupling of two carboxylic esters using impure metallic sodium to yield an α-hydroxyketone, also known as an acyloin. [1] [2] [3] The acyloin condensation. The reaction is most successful when R is aliphatic and saturated, and typically performed with a silyl chloride reactant to trap the product as a ...
A ring forming reaction or ring-closing reaction in organic chemistry is an umbrella term for a variety of reactions that introduce one or more rings into a molecule. A heterocycle forming reaction is a reaction that introduces a new heterocycle.
The Dieckmann condensation, where a molecule with two ester groups reacts intramolecularly, forming a cyclic β-keto ester. In this case, the ring formed must not be strained, usually a 5- or 6-membered chain or ring. Retro-Claisen condensation is the reverse of the title reaction, i.e., the base-induced cleavage of 2-ketoesters
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The Conrad-Limpach reaction mechanism also involves multiple keto-enol tautomerizations, all of which are catalyzed through the use of a strong acid, often HCl or H 2 SO 4. With much of the literature on the synthesis of quinolines , there is some discrepancy on whether a substituted 4-hydroxyquinoline or a substituted 4-quinolone is the final ...
The reaction mechanism involves the acylation and activation of the acid 1 to the mixed anhydride 3. The amide will serve as a nucleophile for the cyclization forming the azlactone 4. Deprotonation and acylation of the azlactone forms the key carbon-carbon bond. Subsequent ring-opening of 6 and decarboxylation give the final keto-amide product.