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It can be considered as a specific variation of the aldol condensation. This reaction is named after two of its pioneering investigators Rainer Ludwig Claisen and J. Gustav Schmidt, who independently published on this topic in 1880 and 1881. [1] [2] [3] An example is the synthesis of dibenzylideneacetone ((1E, 4E)-1,5-diphenylpenta-1,4-dien-3 ...
The Dieckmann condensation, where a molecule with two ester groups reacts intramolecularly, forming a cyclic β-keto ester. In this case, the ring formed must not be strained, usually a 5- or 6-membered chain or ring. Retro-Claisen condensation is the reverse of the title reaction, i.e., the base-induced cleavage of 2-ketoesters
In organic chemistry, the Schmidt reaction is an organic reaction in which an azide reacts with a carbonyl derivative, usually an aldehyde, ketone, or carboxylic acid
Described the condensation of aromatic aldehydes with aliphatic aldehydes or ketones in 1881. This variation of the now well-known aldol condensation reaction is called the Claisen–Schmidt condensation. Discovered (1887) the condensation reaction of an ester with an activated methylene group, now known as the Claisen condensation.
The Claisen rearrangement is a powerful carbon–carbon bond-forming chemical reaction discovered by Rainer Ludwig Claisen. [1] The heating of an allyl vinyl ether will initiate a [3,3]-sigmatropic rearrangement to give a γ,δ-unsaturated carbonyl, driven by exergonically favored carbonyl CO bond formation Δ(Δ f H) = −327 kcal/mol (−1,370 kJ/mol).
Claisen condensation; Claisen rearrangement; Claisen–Schmidt condensation; Clemmensen reduction; Collins reagent; Combes quinoline synthesis; Conia reaction; Conrad–Limpach synthesis; Cook–Heilbron thiazole synthesis; Cope elimination; Cope rearrangement [24] Corey reagent; Corey–Bakshi–Shibata reduction; Corey–Fuchs reaction; Corey ...
Claisen-Schmidt condensation between an aldehyde or ketone having an α-hydrogen with an aromatic carbonyl compound lacking an α-hydrogen. A Claisen condensation involves two ester compounds. A Dieckmann condensation involves two ester groups in the same molecule and yields a cyclic molecule
An important product of the Fischer-Fink synthesis was ethyl 4,5-dimethylpyrrole-2-carboxylate, made from ethyl 2-oximinoacetoacetate and 2-methyl-3-oxobutanal, in turn made by the Claisen condensation of 2-butanone with ethyl formate. [12]