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Neisseria sicca is a commensal organism belonging to the genus Neisseria. It is Gram-negative and oxidase-positive. There are multiple strains of this species, some of which are reported to have caused septicaemia in immunocompromised patients. These bacteria are the first among Neisseria species to have been shown to have O-repeat structure in ...
Penicillinase-mediated resistance in N. gonorrhoeae is mediated by the plasmid borne TEM-1 type beta-lactamase which falls under the third general mechanism for beta-lactam resistance. [2] There have been over 200 beta-lactamases described and some of them are antibiotic specific. [7] TEM-1 is a penicillinase specific for penicillins.
The other type of beta-lactamase is of the metallo type ("type B"). Metallo-beta-lactamases (MBLs) need metal ion(s) (1 or 2 Zn 2+ ions [2]) on their active site for their catalytic activities. [3] The structure of the New Delhi metallo-beta-lactamase 1 is given by 6C89. It resembles a RNase Z, from which it is thought to have evolved.
The International Pathogenic Neisseria Conference (IPNC), occurring every two years, is a forum for the presentation of cutting-edge research on all aspects of the genus Neisseria. This includes immunology, vaccinology, and physiology and metabolism of N. meningitidis , N. gonorrhoeae and the commensal species.
The Neisseriaceae are a family [2] of Pseudomonadota, within the Neisseriales order of Betaproteobacteria.While many organisms in the family are mammalian commensals or part of the normal flora, the genus Neisseria includes two important human pathogens, specifically those responsible for gonorrhea (caused by N. gonorrhoeae) and many cases of meningitis ("meningococcal meningitis", caused by N ...
Drugs commonly used to treat gram negative infections include amino, carboxy and ureido penicillins (ampicillin, amoxicillin, pipercillin, ticarcillin). These drugs may be combined with beta-lactamase inhibitors to combat the presence of enzymes that can digest these drugs (known as beta-lactamases) in the peri-plasmic space
Penicillin is effective for bacteremia caused by non-beta lactamase producing bacteria. However, other agents should be used for the therapy of bacteremia caused by beta-lactamase producing bacteria. Because the length of therapy for anaerobic infections is generally longer than for infections due to aerobic and facultative anaerobic bacteria ...
Nitrocefin is a chromogenic cephalosporin substrate routinely used to detect the presence of beta-lactamase enzymes produced by various microbes. Beta-lactamase mediated resistance to beta-lactam antibiotics such as penicillin is a widespread mechanism of resistance for a number of bacteria including members of the family Enterobacteriaceae, a major group of enteric Gram-negative bacteria.