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The atypical antipsychotics (AAP), also known as second generation antipsychotics (SGAs) and serotonin–dopamine antagonists (SDAs), [1] [2] are a group of antipsychotic drugs (antipsychotic drugs in general are also known as tranquilizers and neuroleptics, although the latter is usually reserved for the typical antipsychotics) largely introduced after the 1970s and used to treat psychiatric ...
There is a risk of developing a serious condition called tardive dyskinesia as a side effect of antipsychotics, including typical antipsychotics. The risk of developing tardive dyskinesia after chronic typical antipsychotic usage varies on several factors, such as age and gender, as well as the specific antipsychotic used.
Segesterone acetate (SGA), sold under the brand name Nestorone among others, is a progestin medication which is used in birth control and in the treatment of endometriosis. [ 1 ] [ 7 ] It is available both alone and in combination with an estrogen as segesterone acetate/ethinylestradiol .
Neuroleptic malignant syndrome (NMS) is a rare [5] [6] but life-threatening reaction that can occur in response to antipsychotics (neuroleptic) or other drugs that block the effects of dopamine. [ 1 ] [ 7 ] Symptoms include high fever , confusion, rigid muscles, variable blood pressure, sweating, and fast heart rate. [ 1 ]
The drug regulates behaviour and thoughts, and can also exhibit an anti-depressive effect. [3] [8] The side effect profile is similar to related antipsychotic agents, displaying weight gain, mental distress, and inability to sit still. Other possible symptoms include anticholinergic side effects such as insomnia, blurred vision, and dry mouth.
Common side effects include movement problems, sleepiness, dry mouth, low blood pressure upon standing, and increased weight. [6] Serious side effects may include the potentially permanent movement disorder tardive dyskinesia , neuroleptic malignant syndrome , severe lowering of the seizure threshold , and low white blood cell levels . [ 6 ]
Type A: augmented pharmacological effects, which are dose-dependent and predictable [5]; Type A reactions, which constitute approximately 80% of adverse drug reactions, are usually a consequence of the drug's primary pharmacological effect (e.g., bleeding when using the anticoagulant warfarin) or a low therapeutic index of the drug (e.g., nausea from digoxin), and they are therefore predictable.