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It includes a recommendation that the State of Michigan set advisory limits for PFAS other than PFOA and PFOS, and for the state to develop new drinking water standards "based on weight of evidence and convergence of toxicological and epidemiological data", suggesting that the current national advisory level of 70 ppt for PFOA + PFOS may be too ...
Perfluorooctanoic acid (PFOA; conjugate base perfluorooctanoate; also known colloquially as C8, for its 8-carbon chain structure) is a perfluorinated carboxylic acid produced and used worldwide as an industrial surfactant in chemical processes and as a material feedstock.
The Swedish National Food Agency recommends a drinking water limit of 0.09 μg/L for the sum of 11 PFASs (PFBS, PFHxS, PFOS, 6:2 FTSA, PFBA, PFPeA, PFHxA, PFHpA, PFOA, PFNA and PFDA). If PFASs are found above this limit in drinking water, immediate action is recommended to reduce the PFAS concentration in the drinking water to as far below the ...
Skeletal structure of PFOS, an effective, persistent and bioaccumulative fluorosurfactant A physical sample of PFOA, appearing as a white solid as seen here in a relatively pure form. It is commonly referred to as the main harmful PFAS chemical and PFOA is responsible for many of the negative health effects commonly associated with PFAS.
In addition, PFOSA is thought to be the biologically active form of the insecticide Sulfluramid (N-ethyl perfluorooctanesulfonamide) [9] [10] as it is an extremely potent uncoupler of oxidative phosphorylation [10] [11] with an IC 50 of about 1 micromolar [5] (≈500 nanograms per milliliter or parts per billion).
In 1968, organofluorine compounds were detected in the blood serum of consumers, and in 1976, perfluorooctanoic acid (PFOA) or a related compound such as PFOS were suggested as components. [ 6 ] [ 7 ] [ 8 ] In 1997, 3M detected PFOS in blood from global blood banks, [ 9 ] although the company's internal documents indicate knowledge of this ...
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