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Progesterone is used as part of hormone replacement therapy in people who have low progesterone levels, and for other reasons. For purposes of comparison with normal physiological circumstances, luteal phase levels of progesterone are 4 to 30 ng/mL, while follicular phase levels of progesterone are 0.02 to 0.9 ng/mL, menopausal levels are 0.03 to 0.3 ng/mL, and levels of progesterone in men ...
Progesterone pharmacokinetics by route [1] [2] Route Form Dose C max (ng/mL) T max (hours) t 1/2 (hours) Oral: Capsule: 200 mg: 4.3–11.7: 2–2.5? Sublingual: Tablet [a] 100 mg: 13.5: 1–4 ~6–7 Suspension: 100 mg: 17.6: 0.5–1? Vaginal: Tablet [a] 100 mg: 10.9: 6–7: 13.7 Capsule: 100 mg: 9.7: 1–3? Intramuscular injection: Oil solution ...
Ethinylestradiol and norethisterone acetate (FemHRT) – 25 μg / 0.5 mg; Estradiol/progesterone (TX-001HR), a combination of estradiol and progesterone in oil-filled capsules, is currently pending approval. [45] Estradiol and norgestimate (Prefest; 1 mg / 90 μg) was previously available in the U.S. but was discontinued.
[312] [313] In one study, 100 mg rectal suppositories of progesterone given five times per day for 9 days resulted in progesterone levels of 5.5 to 29 ng/mL and suppressed circulating testosterone and growth hormone levels by about 50% in men, but did not affect libido or erectile potency in this short treatment period.
Transdermal progesterone is often used as a component of compounded BHT but has not been clinically proven to prevent endometrial hyperplasia, as oral progesterone has. [25] The editors-in-chief of the scientific journal Climacteric state that the greatest difference in function between bioidentical and synthetic hormones may be found in ...
17α-Acetoxy-6-chloro-1,6-didehydro-progesterone Flugestone acetate (flurogestone acetate) 17α-Acetoxy-9α-fluoro-11β-hydroxyprogesterone Flumedroxone acetate: 17α-Acetoxy-6α-(trifluoromethyl)progesterone Hydroxyprogesterone acetate: 17α-Acetoxyprogesterone Hydroxyprogesterone caproate: 17α-Hexanoxyprogesterone Hydroxyprogesterone heptanoate
The brand version, Progesterone, is around $450 for 30 capsules without any discounts or insurance applied. [178] In comparison, Walgreens offers 30 capsules of 100 mg in the generic version for $51 without insurance or coupons applied. The brand name costs around $431 for 30 capsules of 100 mg. [179]
In 1952, Rock induced a three-month anovulatory "pseudopregnancy" state in eighty of his infertility patients with continuous gradually increasing oral doses of an estrogen (5 to 30 mg/day diethylstilbestrol) and progesterone (50 to 300 mg/day), and within the following four months 15% of the women became pregnant. [186] [189] [190]
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