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Autoimmune autonomic ganglionopathy is a type of immune-mediated autonomic failure that is associated with antibodies against the ganglionic nicotinic acetylcholine receptor present in sympathetic, parasympathetic, and enteric ganglia. Typical symptoms include gastrointestinal dysmotility, orthostatic hypotension, and tonic pupils. [1]
The cysts may intrude into the spine, which may cause pain and dysesthesia in distant extremities. [ 20 ] Cystic adventitial disease , in which a cyst occurs within the popliteal artery near the knee, has been proposed recently to occur by an articular mechanism, with a conduit leading from the joint, similar to the development of ganglion ...
The most common presentation is a palsy of the deep motor branch of the ulnar nerve causing weakness of the interosseous muscles. Ulnar tunnel syndrome is usually caused by a ganglion cyst pressing on the ulnar nerve, other causes include traumas to the wrist and repetitive movements, but often the cause is unknown (idiopathic). [2]
However, some autoimmune diseases may present with more specific symptoms such as joint pain, skin rashes (e.g., urticaria), or neurological symptoms. The exact causes of autoimmune diseases remain unclear and are likely multifactorial, involving both genetic and environmental influences. [7]
IBM is often confused with an entirely different class of diseases, called hereditary inclusion body myopathies (hIBM). [4] [5] The "M" in hIBM is an abbreviation for "myopathy" while the "M" in IBM is for "myositis". [6] In IBM, two processes appear to occur in the muscles in parallel, one autoimmune and the other degenerative.
Antisynthetase syndrome (ASS) is a multisystematic autoimmune disease associated with inflammatory myositis, interstitial lung disease, and antibodies directed against various synthetases of aminoacyl-transfer RNA. [3] Other common symptoms include mechanic's hands, Raynaud's phenomenon, arthritis, and fever. [4]
Treatment of dysautonomia can be difficult; since it is made up of many different symptoms, a combination of drug therapies is often required to manage individual symptomatic complaints. In the case of autoimmune neuropathy, treatment with immunomodulatory therapies is done. If diabetes mellitus is the cause, control of blood glucose is ...
The appearance of erosions and destruction, however, is exceedingly rare and this may point instead to rheumatoid arthritis as a cause. [3] Diseases and inflammation of tendons have been reported in small numbers of people with RP. [3] During the course of the disease, around 80% of people develop joint symptoms. [3]