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Cimetidine is rapidly absorbed regardless of route of administration. [7] The oral bioavailability of cimetidine is 60 to 70%. [5] [6] The onset of action of cimetidine when taken orally is 30 minutes, [8] and peak levels occur within 1 to 3 hours. [5] Cimetidine is widely distributed throughout all tissues. [7]
Cimetidine was the prototypical histamine H 2 receptor antagonist from which later drugs were developed. Cimetidine was the culmination of a project at Smith, Kline & French (SK&F; now GlaxoSmithKline) by James W. Black, C. Robin Ganellin, and others to develop a histamine receptor antagonist that would suppress stomach acid secretion.
Antihistamines are drugs which treat allergic rhinitis, common cold, influenza, and other allergies. [1] Typically, people take antihistamines as an inexpensive, generic (not patented) drug that can be bought without a prescription and provides relief from nasal congestion, sneezing, or hives caused by pollen, dust mites, or animal allergy with few side effects. [1]
The Pursteam 10-in-1 steam mop has a 4.2-star average rating from almost 50,000 reviews on Amazon. You can use this on hardwood floors, carpet, tile and laminate, and it heats water in as fast as ...
Nizatidine was developed by Eli Lilly, and was first marketed in 1988. [3] It is considered to be equipotent with ranitidine and differs by the substitution of a thiazole ring in place of the furan ring in ranitidine.
This is often called linear pharmacokinetics, as the change in concentration over time can be expressed as a linear differential equation =. Assuming a single IV bolus dose resulting in a concentration C initial {\displaystyle C_{\text{initial}}} at time t = 0 {\displaystyle t=0} , the equation can be solved to give C = C initial × e − k el ...
The term "fine chemicals" was in use as early as 1908. [1] The emergence of the fine chemical industry as a distinct entity dates to the late 1970s, when the overwhelming success of the histamine H 2 receptor antagonists Tagamet (cimetidine) and Zantac (ranitidine hydrochloride) created a strong demand for advanced organic chemicals used in their manufacture.
Bromazepam, sold under many brand names, is a benzodiazepine.It is mainly an anti-anxiety agent with similar side effects to diazepam.In addition to being used to treat anxiety or panic states, bromazepam may be used as a premedicant prior to minor surgery.
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