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Genes encoding human Ly6 family members are located in clusters on chromosomes 6, 8, 11 and 19. In the murine genome family members are located on chromosomes 17, 15, 9 and 7, respectively. [ 4 ] [ 3 ] [ 1 ] Genes encoding Ly6 proteins with one LU domain consist of 3 exons and 2 introns .
79136 n/a Ensembl ENSG00000255552 n/a UniProt n a n/a RefSeq (mRNA) NM_001003721 NM_024123 n/a RefSeq (protein) n/a n/a Location (UCSC) n/a n/a PubMed search n/a Wikidata View/Edit Human Lymphocyte antigen 6 complex, locus G6E (pseudogene) is a protein that in humans is encoded by the LY6G6E gene. Function LY6G6E belongs to a cluster of leukocyte antigen-6 (LY6) genes located in the major ...
Ly6/neurotoxin 1 is a protein in humans that is encoded by the LYNX1 gene. [5] Alternatively spliced variants encoding different isoforms have been identified. Function
Lymphocyte antigen 6E is a protein that in humans is encoded by the LY6E gene. [5] [6] [7] Increased expression of Ly6E is associated with poor survival outcome in multiple malignancies as determined by a survey of more than 130 published clinical studies of gene expression studies on cancer tissue samples and adjacent normal tissues. [8]
A duplication of the gene has been detected in a case study of two individuals with severe intellectual disability, suggesting its role in proper brain development and cognitive function. [10] Additionally, the protein demonstrates high expression in several other normal organs including the testis , lungs , stomach , and prostate .
Sca-1 stands for "Stem cells antigen-1" (official gene symbol: Ly6a). It consist of 18-kDa mouse glycosyl phosphatidylinositol-anchored cell surface protein (GPI-AP) of the LY6 gene family. [1] It is the common biological marker used to identify hematopoietic stem cell (HSC) along with other markers.
CD59 glycoprotein, also known as MAC-inhibitory protein (MAC-IP), membrane inhibitor of reactive lysis (MIRL), or protectin, is a protein that in humans is encoded by the CD59 gene. [5] It is an LU domain and belongs to the LY6/uPAR/alpha-neurotoxin protein family. [6] CD59 attaches to host cells via a glycophosphatidylinositol (GPI) anchor.
LY6/PLAUR domain containing 8 is a protein that in humans is encoded by the LYPD8 gene. [5] References